Results 51 to 60 of about 63,533 (294)

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF [PDF]

, 2013
Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases.
Albanese CT, An Staes, Carlos López‐Otin, Claude Libert, Elien Van Wonterghem, Eline Dejonckheere, Filip Van Hauwermeiren, Kitagawa H, Kris Gevaert, Lesuffleur T, Nusrat A, Riet De Rycke, Roosmarijn E. Vandenbroucke, Schmitz H, Smirnova MG, Sofie Lodens   +15 more
core   +3 more sources

Rare presentations of small bowel endometriosis

DEN Open
Despite endometriosis being a relatively common chronic gynecological condition in women of childbearing age, small bowel endometriosis is rare. Presentations can vary from completely asymptomatic to reported symptoms of abdominal pain, bloating, and ...
Anthony Sakiris, Ezaam Naik Fraz, Arvinf Rajandran, Jason Smith, Benjamin Allen, Sooraj Pillai, Pradeep Kakkadasam Ramaswamy, Sneha John   +7 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Ileocolic Intussusception in Adults: A Rare Presentation of an Underlying Malignancy

Acta Médica Portuguesa
N ...
Catarina Rolo Santos, Frederico Nazareth, Zara Maria Caetano   +2 more
doaj   +1 more source

Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s disease

Nature Communications, 2023
Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson’s disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn).
Rhonda L. McFleder, Anastasiia Makhotkina, Janos Groh, Ursula Keber, Fabian Imdahl, Josefina Peña Mosca, Alina Peteranderl, Jingjing Wu, Sawako Tabuchi, Jan Hoffmann, Ann-Kathrin Karl, Axel Pagenstecher, Jörg Vogel, Andreas Beilhack, James B. Koprich, Jonathan M. Brotchie, Antoine-Emmanuel Saliba, Jens Volkmann, Chi Wang Ip   +18 more
doaj   +1 more source

Ileal pouch-anal anastomosis for Crohn’s disease [PDF]

Gut, 1998
Over the past 10 years ileal pouch-anal anastomosis has become the operation of choice for most patients with ulcerative colitis. Although pouch surgery in ulcerative colitis does have a moderate complication rate, so do the alternatives of proctocolectomy and ileostomy.1 The very real advantage of avoiding a stoma along with the inherent curability of
openaire   +2 more sources

Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine [PDF]

, 2012
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin (IgG) across epithelia to confer passive immunity to mammalian young. In newborn rodents, FcRn transcytoses IgG from ingested milk across the intestinal epithelium for release into the ...
Bjorkman, Pamela J., Huey-Tubman, Kathryn E., Ladinsky, Mark S.   +2 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Idiopathic Primary Calcium Oxalate‐Rich Enteroliths Causing Small Bowel Obstruction in a Young Woman: A Rare Case Report

Clinical Case Reports
Primary enterolithiasis must be considered in subacute bowel obstruction, even in patients lacking classic risk factors. Persistent, unexplained abdominal symptoms necessitate repeat imaging and heightened clinical suspicion, as timely surgical resection
Usama Hanif, Abdur Rehman, Hafsa Azam Arshad Raja, Ibia Nawaz, Muhammad Iqbal, Usman Qureshi, Sidra Yousaf, Rahmat Gul Omarzai   +7 more
doaj   +1 more source