Results 61 to 70 of about 35,795 (270)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Idiopathic Primary Calcium Oxalate‐Rich Enteroliths Causing Small Bowel Obstruction in a Young Woman: A Rare Case Report

Clinical Case Reports
Primary enterolithiasis must be considered in subacute bowel obstruction, even in patients lacking classic risk factors. Persistent, unexplained abdominal symptoms necessitate repeat imaging and heightened clinical suspicion, as timely surgical resection
Usama Hanif, Abdur Rehman, Hafsa Azam Arshad Raja, Ibia Nawaz, Muhammad Iqbal, Usman Qureshi, Sidra Yousaf, Rahmat Gul Omarzai   +7 more
doaj   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice.

PLoS ONE, 2021
Ursodeoxycholic acid (commercially available as ursodiol) is a naturally occurring bile acid that is used to treat a variety of hepatic and gastrointestinal diseases.
Jenessa A Winston, Alissa Rivera, Jingwei Cai, Andrew D Patterson, Casey M Theriot   +4 more
doaj   +1 more source

Strategy for management of distal ileal Crohn's disease

Journal of British Surgery, 1991
Abstract We have determined the outcome of a defined policy for the management of distal ileal Crohn's disease using a prospective computer-based analysis of 139 patients diagnosed between 1970 and 1988 with a mean follow-up of 10 years. The policy in outline consists of conservative treatment for acute obstructive episodes, resection or
H A, Andrews, M R, Keighley, J, Alexander-Williams, R N, Allan   +3 more
openaire   +2 more sources

Long‐Term Outcomes After Stoma Creation in Crohn's Disease: A Retrospective Cohort Study of 422 Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Stoma creation is often required in Crohn's disease (CD), most commonly because of progressive anorectal disease. As stoma closure strongly influences long‐term quality of life and surgical decision‐making, this study evaluated the indications and long‐term outcomes of stoma creation in patients with CD.
Kentaro Nagano, Ryuichi Kuwahara, Yusuke Tomoo, Kurando Kusunoki, Yuki Horio, Kei Kimura, Kozo Kataoka, Masataka Ikeda, Motoi Uchino, Hiroki Ikeuchi   +9 more
wiley   +1 more source

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer [PDF]

, 2020
The prognosis of colon cancer (CC) is dictated by tumor-infiltrating lymphocytes, including follicular helper T (T-FH) cells and the efficacy of chemotherapy-induced immune responses.
Ivo Gomperts Boneca, Ferrere G., Lehmann C. H. K., Fluckiger A., Malka, David, Lehmann, Christian H. K., Pages, Franck, Sonia Becharef, Chamaillard, Mathias, Ghiringhelli, Francois, Roberti MP, Pietrantonio F, Yonekura, Satoru, Lehmann, Christian,, Vincent A., Opolon, Paule, Roberti, Maria Paula, Lepage P., Valerio Iebba, Richard C., Galon, Jerome, Satoru Yonekura, Marion Picard, Aurélie Fluckiger, Opolon P, Lisa Derosa, Romain Daillère, Lehmann CHK, Marliot F, Tidjani Alou M, Rauber C, Dudziak D., Dudziak D, Ryffel B, Hollebecque A, Alou, Maryam Tidjani, Duong C. P. M., Fluckiger A, Amon, Lukas, Daillere R., Pagès F, Didier Raoult, Zitvogel, Laurence, Ly, Pierre, Flament C, Tom Vanden Berghe, Paillet, Juliette, Mathias Chamaillard, Duong, Connie, P. M., Fluckiger, Aurelie, Daillere, Romain, Rauber, Conrad, Paillet J., Maryam Tidjani Alou, Ly P., Vandenabeele P, Juliette Paillet, Gomperts Boneca, Ivo, Flament C., Ghiringhelli F., Kroemer, Guido, Pietrantonio F., Iebba, Valerio, Chamaillard M, Picard, Marion, Pierre Ly, Duong, Connie P. M., Conrad Rauber, Bertrand Routy, Antoine Hollebecque, Malka D., Richard C, Raoult D., Klein C, Peggy Dartigues, Rauber C., Yonekura S., Maria Paula Roberti, Pizzato E, Vincent A, Gomperts Boneca I., Galon J, Jean-Yves Scoazec, Marliot F., Christophe Klein, Pages F., Amon L, Scoazec JY, Caroline Flament, Benoist S, Van Seuningen I, Dartigues, Peggy, Connie P. M. Duong, Lepage P, François Ghiringhelli, Christian H. K. Lehmann, Alexander Eggermont, Dartigues P., Dartigues P, Lehmann, Christian, H. K., Stephanie Kourula, Kroemer G., Corentin Richard, Flament, Caroline, Boneca, Ivo Gomperts, Picard M., Paillet J, Derosa, Lisa, Marliot, Florence, Tidjani Alou M., Ghiringhelli F, Diana Dudziak, Van Seuningen I., Gladys Ferrere, Ferrere, Gladys, Kroemer G, David Malka, Duong CPM, Van Seuningen, Isabelle, Vanden Berghe, Tom, Vandenabeele P., Pietrantonio, Filippo, Chamaillard M., Hollebecque A., Amon L., Richard, Corentin, Kourula S., Vandenabeele, Peter, Ly P, Lukas Amon, Stéphane Benoist, Eggermont A, Yonekura S, Audrey Vincent, Tidjani Alou, Maryam, Jérôme Galon, Kourula, Stephanie, Hollebecque, Antoine, Franck Pagès, Iebba V, Isabelle Van Seuningen, Florence Marliot, Becharef S, Gomperts Boneca I, Bernard Ryffel, Scoazec J. -Y., Raoult D, Pizzato E., Klein C., Benoist S., Routy B, Kourula S, Patricia Lepage, Vincent, Audrey, Becharef, Sonia, Daillère R, Klein, Christophe, Zitvogel L., Dudziak, Diana, Benoist, Stephane, Routy B., Galon J., Ryffel B., Eugénie Pizzato, Vanden Berghe T., Malka D, Pizzato, Eugenie, Picard M, Eggermont A., Ferrere G, Duong, Connie,, Scoazec, Jean-Yves, Becharef S., Eggermont, Alexander, Derosa L., Filippo Pietrantonio, Iebba V., Roberti M. P., Paule Opolon, Ryffel, Bernhard, Routy, Bertrand, Derosa L, Laurence Zitvogel, Opolon P., Lepage, Patricia, Vanden Berghe T, Ryffel, Bernard, Raoult, Didier, Guido Kroemer, Peter Vandenabeele   +189 more
core   +1 more source

Pre-Weaning Inulin Supplementation Alters the Ileal Transcriptome in Pigs Regarding Lipid Metabolism. [PDF]

, 2021
peer reviewedPrebiotics, such as inulin, are non-digestible compounds that stimulate the growth of beneficial microbiota, which results in improved gut and overall health.
Deforce, Dieter, Dieter Deforce, Yuping Zhang, Everaert, Nadia, Ester Arévalo Sureda, Julie Leblois, Wavreille, José, Li, Bing, Martine Schroyen, Nadia Everaert, Arevalo Sureda, Ester, Zhang, Yuping, Schroyen, Martine, Bing Li, José Wavreille, Filip Van Nieuwerburgh, Leblois, Julie, Van Nieuwerburgh, Filip   +17 more
core   +1 more source

Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn’s disease

JCI Insight, 2022
Elucidating how resident enteric bacteria interact with their hosts to promote health or inflammation is of central importance to diarrheal and inflammatory bowel diseases across species. Here, we integrated the microbial and chemical microenvironment of
Shiying Zhang, Xochitl Morgan, Belgin Dogan, Francois-Pierre Martin, Suzy Strickler, Akihiko Oka, Jeremy Herzog, Bo Liu, Scot E. Dowd, Curtis Huttenhower, Matthieu Pichaud, Esra I. Dogan, Jack Satsangi, Randy Longman, Rhonda Yantiss, Lukas A. Mueller, Ellen J. Scherl, R. Balfour Sartor, Kenneth W. Simpson   +18 more
doaj   +1 more source