Results 81 to 90 of about 2,175,268 (253)

Intestinal epithelial Smad7 drives purine metabolic dysregulation and ileal inflammation

Journal of Biomedical Science
Background and aims Defects of the gut epithelial barrier and counter-regulatory mechanisms are a prerequisite for the onset of intestinal inflammation in patients with inflammatory bowel diseases (IBD).
Federica Laudisi, Mattia Alberto Serra, Lorenzo Tomassini, Massimo Claudio Fantini, Gustavo Monasterio, Ning He, Eduardo Maria Sommella, Angela Ortenzi, Giuseppe Sigismondo Sica, Francesca Zorzi, Teresa Pacifico, Ombretta Melaiu, Cristiano De Stefanis, Valentina D’Oria, Carmine Stolfi, Ivan Monteleone, Eduardo Javier Villablanca, Giovanni Monteleone   +17 more
doaj   +1 more source

Fluoride induces hepatointestinal damage and vitamin B2 mitigation by regulating IL-17A and Bifidobacterium in ileum

Journal of Advanced Research
Introduction: Fluorosis is a global public health disease affecting more than 50 countries and 500 million people. Excessive fluoride damages the liver and intestines, yet the mechanisms and therapeutic approaches remain unclear.
Chen Liang, Cuicui Zhuang, Chenkai Cheng, Jian Bai, Yue Wu, Xiang Li, Jie Yang, Bohui Li, Weixiang Fu, Qianlong Zhu, Jiawei Lv, Yanjia Tan, Ram Kumar Manthari, Yangfei Zhao, Jundong Wang, Jianhai Zhang   +15 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Complicated Acute Appendicitis Conservatively Treated in Two Patients With Crohn's Disease: The Role of Intestinal Ultrasound and Contrast‐Enhanced Ultrasound

Journal of Clinical Ultrasound, EarlyView.
Intestinal ultrasound and contrast‐enhanced ultrasound were used to diagnose, monitor, and guide conservative treatment of complicated acute appendicitis in two patients with Crohn's disease. Serial imaging enabled early identification of treatment response, allowing long‐term surgery‐free outcomes.
Cataletti Giovanni, Gridavilla Daniele, Nylund Kim, Colombo Francesco, Danelli Piergiorgio, Maconi Giovanni   +5 more
wiley   +1 more source

In vitro synergy of sertraline and tetracycline cannot be reproduced in pigs orally challenged with a tetracycline resistant Escherichia coli

BMC Microbiology, 2019
Background Antimicrobial helper-compounds may reverse antimicrobial resistance. Sertraline, a antidepressant drug, has been suggested as a tetracycline helper-compound. Tetracycline is the preferred antimicrobial for treatment of enteric diseases in pigs.
Sofie Kromann, Anna Hvidtfeldt, Mette Boye, Dorte Bratbo Sørensen, Steffen Jørgensen, Jens Peter Nielsen, Rikke Heidemann Olsen   +6 more
doaj   +1 more source

Incidental Detection of Portal Venous Gas During POCUS in a Neonate With Necrotizing Enterocolitis and Intestinal Perforation: A Case Report

Journal of Clinical Ultrasound, EarlyView.
Point‐of‐care ultrasound performed at the bedside identified hepatic portal venous gas in a critically ill neonate, prompting urgent evaluation and revealing intestinal perforation due to necrotizing enterocolitis. This case highlights the potential of POCUS to accelerate diagnosis when clinical signs are subtle or nonspecific.
Tiago Henrique de Souza, Elisa Caixeta Fallieri Nascimento, Fernando de Lima Carioca, Nayara Hillebrand Franzon, Humberto Magalhães Silva   +4 more
wiley   +1 more source

Old disease, new twist

Journal of Hospital Medicine, EarlyView.
Abstract An 81‐year‐old man with a history of high‐grade urothelial carcinoma of the bladder and ureter on treatment with atezolizumab and tiragolumab presented to the emergency department with 5 months of malaise, generalized weakness, and fatigue and 2 weeks of subjective fevers. One month prior to presentation, he received an empiric 9‐day course of
Hadi Roudsari, Gurpreet Dhaliwal, Anand D. Jagannath, Alan H. Baik, Sam Brondfield   +4 more
wiley   +1 more source

Protective Effects of Beta-3 Adrenoceptor Agonism on Mucosal Integrity in Hyperoxia-Induced Ileal Alterations

Antioxidants
Organogenesis occurs in the uterus under low oxygen levels (4%). Preterm birth exposes immature newborns to a hyperoxic environment, which can induce a massive production of reactive oxygen species and potentially affect organ development, leading to ...
Patrizia Nardini, Virginia Zizi, Marta Molino, Camilla Fazi, Maura Calvani, Francesco Carrozzo, Giorgia Giuseppetti, Laura Calosi, Daniele Guasti, Denise Biagini, Fabio Di Francesco, Luca Filippi, Alessandro Pini   +12 more
doaj   +1 more source

Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized that gut microbial ecology would differ across these disorders. Methods Stool was collected from 120 subjects (AP [n = 30], CD
Neha R. Santucci, Chinenye R. Dike, Jenny Hellmann, Nicholas J. Ollberding, Qing Duan, Philip Minar, Lee A. Denson, David B. Haslam, Daniel Castillo, Maisam Abu‐El‐Haija   +9 more
wiley   +1 more source