Results 11 to 20 of about 125,494 (213)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Evaluation of the Conrad N. Hilton Foundation Chronic Homelessness Initiative: 2015 [PDF]

open access: yes, 2015
Under a September 2011 contract with the Conrad N. Hilton Foundation, Abt Associates has been conducting an evaluation of the Hilton Foundation's Chronic Homelessness Initiative, with the goal of answering the overarching question: Is the Chronic ...

core  

Barreras y facilitadores en el acceso y la utilización de los centros de atención primaria para las personas en situación de sinhogarismo

open access: yesAtención Primaria
Resumen: Objetivo: Identificar las barreras y los facilitadores en el acceso y la utilización de los centros de atención primaria para las personas en situación de sinhogarismo.
María Sánchez Hidalgo   +5 more
doaj   +1 more source

Strengthening Ontario\u27s System of Housing for People with Serious Mental Illness [PDF]

open access: yes, 2007
This article describes recent work to support recommendations for improving Ontario’s system of housing for people with serious mental illness. This multifaceted project engaged stakeholders in discussions concerning strategies for improving the system ...
Aubry, Tim   +5 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Out-of-home care placement, psychiatric disorders, and risk of homelessness: a population-based cohort studyResearch in context

open access: yesThe Lancet Regional Health. Europe
Summary: Background: Family adversity and childhood abuse have been associated with an increased risk of homelessness in adulthood. However, to our knowledge, no population-based longitudinal studies have examined the association between out-of-home ...
Sandra Feodor Nilsson   +5 more
doaj   +1 more source

2016 Annual Report on the State of Homelessness in WNY [PDF]

open access: yes, 2017
The Homeless Alliance of Western New York is the designated Continuum of Care (CoC) agency for Erie County that is responsible for compiling the annual Continuum of Care grant from the Department of Housing and Urban Development (HUD). In 2011 this grant
Homeless Alliance of New York
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Factors influencing the length of hospital stay of people experiencing homelessness

open access: yesFrontiers in Public Health
IntroductionPeople experiencing homelessness (PEH) are affected by poor mental and physical health. Crucial healthcare remains inaccessible. In urgent need, people seek assistance in hospitals.
Renate Karpenko   +3 more
doaj   +1 more source

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