Results 21 to 30 of about 16,984 (236)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Barreras y facilitadores en el acceso y la utilización de los centros de atención primaria para las personas en situación de sinhogarismo

Atención Primaria
Resumen: Objetivo: Identificar las barreras y los facilitadores en el acceso y la utilización de los centros de atención primaria para las personas en situación de sinhogarismo.
María Sánchez Hidalgo, Maria Sol Andrés, Josepa Canadell Rusiñol, Laura Paloma Fürstenheim Milerud, Estela Gómez Palomar, Marta Moya Tena   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Out-of-home care placement, psychiatric disorders, and risk of homelessness: a population-based cohort studyResearch in context

The Lancet Regional Health. Europe
Summary: Background: Family adversity and childhood abuse have been associated with an increased risk of homelessness in adulthood. However, to our knowledge, no population-based longitudinal studies have examined the association between out-of-home ...
Sandra Feodor Nilsson, Thomas Munk Laursen, Anne Ranning, Anne A.E. Thorup, Merete Nordentoft, Seena Fazel   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Service provision and barriers to care for homeless people with mental health problems across 14 European capital cities

, 2012
Background Mental health problems are disproportionately higher amongst homeless people. Many barriers exist for homeless people with mental health problems in accessing treatment yet little research has been done on service provision and quality of care
Greacen, Tim, Straßmayr, Christa, Jacek Moskalewicz, Soares, Joaquim, Kluge Ulrike, Barry Margaret M, Priebe, Stefan, Schene, AH, Holcnerova, Petra, Gaddini, Andrea, Soares Joaquim J F, Diaz-Olalla, Jose Manuel, Petra Holcnerová, Soares, JJF, Gaddini Andrea, Barry, Margaret M, Aleksandra Matanov, Margaret M Barry, Barry, Margaret M., Barros, H, Greacen, T, Greacen Tim, Canavan, Reamonn, Díaz-Olalla José, Barros, Henrique, Kluge, U, Schene, Aart, Moskalewicz, Jacek, Aart H Schene, Manuel Diaz-Olalla, J, Priebe, S, Matanov, Aleksandra, Schene, Aart H., Nicaise Pablo, Canavan Réamonn, Nicaise, Pablo, Soares, Joaquim J. F.,, Henrique Barros, Canavan, R, Ulrike Kluge, Strassmayr, C, Nicaise, P, Réamonn Canavan, Barros Henrique, Barry, MM, Tim Greacen, Soares, Joaquim J. F., Joaquim J F Soares, Priebe Stefan, Barry, Margaret, Gabor Edina, Stefan Priebe, Matanov Aleksandra, Gabor, E, José Manuel Díaz-Olalla, Holcnerova, P, Holcnerová Petra, Matanov, A, Schene Aart H, Moskalewicz Jacek, Christa Straßmayr, Andrea Gaddini, Schene, Aart H, Pablo Nicaise, Gabor, Edina, Kluge, Ulrike, Edina Gabor, Soares, Joaquim J F, Moskalewicz, J, Straßmayr Christa, Gaddini, A   +70 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Factors influencing the length of hospital stay of people experiencing homelessness

Frontiers in Public Health
IntroductionPeople experiencing homelessness (PEH) are affected by poor mental and physical health. Crucial healthcare remains inaccessible. In urgent need, people seek assistance in hospitals.
Renate Karpenko, Sonia Lech, Liane Schenk, Daniel Schindel   +3 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source