Results 11 to 20 of about 125,946 (236)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Home Not Found: The Cost of Homelessness In Silicon Valley [PDF]
, 2015 This report analyzes comprehensive cross-sector information about the entire population of residents who experienced homelessness in Santa Clara County at any point during a six year period -- a total of 104,206 individuals. This information includes the
Daniel Flaming +2 more
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Atención PrimariaResumen: Objetivo: Identificar las barreras y los facilitadores en el acceso y la utilización de los centros de atención primaria para las personas en situación de sinhogarismo.
María Sánchez Hidalgo +5 more
doaj +1 more source
Project 25: Housing the Most Frequent Users of Public Services Among the Homeless [PDF]
, 2015 The purpose of Project 25 is to investigate whether providing permanent housing with intensive individualized support, coupled with an identified, "Medical Home," can realize a significant reduction in the use and cost of public services.
Lynn Reaser
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Lancet Regional Health. EuropeSummary: Background: Family adversity and childhood abuse have been associated with an increased risk of homelessness in adulthood. However, to our knowledge, no population-based longitudinal studies have examined the association between out-of-home ...
Sandra Feodor Nilsson +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Literature Review: Diverting Mentally Ill Offenders from Jail [PDF]
, 1997 This literature review describes literature available on the topic of diverting mentally ill offenders from jail; outlines major themes found in the literature; analyzed programs described in the literature by type; and highlights recommendations from ...
Crum, Peter, Langworthy, Robert H.
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source