Results 71 to 80 of about 8,860,363 (114)

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, Volume 13, Issue 53, 24 September 2026.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, Volume 13, Issue 53, 24 September 2026.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, Volume 13, Issue 53, 24 September 2026.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen, Ming‐Ying Xiao, Lan‐Lan Guo, Hao‐Yue Hu, Sui‐Xian Zhang, Bai‐Qiang Dong, Chen‐Fei Wu, Xia‐Hang Huang, Li Li, Run‐Zhe Chen, Yuan‐Yang Huang, Ying Jin, Hai Song, Ying Wang, Qi‐Wen Li, Ming Chen, Xuan Li, Yuan‐Yuan Chen   +17 more
wiley   +1 more source

The Oral Microbiome of King Richard III of England

American Journal of Biological Anthropology, Volume 191, Issue 1, September 2026.
ABSTRACT Objectives Metagenomic investigations of ancient dental calculus provide insights into oral health, disease, and diet. Here, we analyze the dental calculus metagenome of King Richard III of England (1452–1485). Materials and Methods Dental calculus DNA was extracted from three teeth of King Richard III and shotgun sequenced to a depth of ...
Irina M. Velsko, Alexander Hübner, Zandra Fagernäs, James A. Fellows Yates, Allison E. Mann, Courtney A. Hofman, Andrew T. Ozga, Cecil M. Lewis Jr., Camilla Speller, Sarah Fiddyment, Michael Francken, Joachim Wahl, Johannes Krause, Anita Radini, Turi King, Christina Warinner   +15 more
wiley   +1 more source

Single‐cell transcriptomic analysis reveals subtle fluctuations of oocyte cryopreservation on mouse early embryo development

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Mature oocytes were subjected to cryopreservation followed by intracytoplasmic sperm injection (ICSI). Embryos at multiple developmental stages were collected, dissociated into single cells and processed for single‐cell library construction and bioinformatics analysis.
Yixin Ren, Qingyang Zhang, Fanqing Xu, Yao Li, Tianyi Liao, Mengyuan Zhao, Zhiqiang Yan, Xiaohui Zhu, Nan Wang, Peng Yuan, Gary D Smith, Jie Qiao, Jie Yan, Liying Yan, Qilong He   +14 more
wiley   +1 more source

Structural and Functional Responses of Root Endophytic Fungi to Fairy Ring Expansion in Alpine Meadows on the Tibetan Plateau

Ecology and Evolution, Volume 16, Issue 9, September 2026.
This study characterizes root endophytic fungal communities across three fairy ring types on the Tibetan Plateau, revealing that community assembly is driven by intra‐kingdom competition that leads to “Symbiotic Decoupling” and the suppression of native mutualists in fungal‐active zones.
Chengxing Wu, Zhihua Wu, Shiting Cao, Sisong Tu, Yuying Zhang, Na Li, Ming Wang, Huiyuan Ren, Qingbo Gao, Shilong Chen, Rui Xing   +10 more
wiley   +1 more source

Mitogenomic Insights Into the Population Structure and Demographic History of Tree Shrews (Tupaia belangeri) in China

Ecology and Evolution, Volume 16, Issue 9, September 2026.
Sample information and genetic landscape of the northern tree shrew. ABSTRACT The northern tree shrew (Tupaia belangeri) exhibits significant morphological and geographical variations, but its evolutionary history and subspecies boundaries remain controversial.
Tongtong Gu, Lijuan Cao, Dongjie Liu, Chengyao Yang, Zixin Lin, Rongxiang Mu, Wanlong Zhu   +6 more
wiley   +1 more source

Proteomic Determinants of Fluctuating Light Sensitivity in Soybean: Comparative Analysis of Tolerant and Sensitive Cultivars

Food and Energy Security, Volume 15, Issue 5, September/October 2026.
ABSTRACT Fluctuating light (FL), caused by cloud movement, canopy dynamics, and intercropping, is a pervasive stress affecting crop productivity, yet the molecular basis of FL responses in different photosensitivity soybeans remains poorly understood. Here, we integrated physiological, transcriptomic, and proteomic analyses to compare the responses to ...
Yuanfang Fan, Sajad Hussain, Marian Brestic, Feng Yang   +3 more
wiley   +1 more source