Results 141 to 150 of about 700,365 (275)

O38: The impact of whole genome sequencing in a diverse global population of genetic disease patients*

Genetics in Medicine Open, 2023
Ryan Taft, Erin Thorpe, John Belmont, Taylor Williams, Chad Shaw, Jason Button, Julia Ortega, Keisha Robinson, Marilyn Jones, Diane Masser-Frye, Donald Basel, Chester Brown, Keith Vaux, Aime Lumaka, Fabio Sirchia, Milagros Dueñas Roque, Mario Cornejo-Olivas, Jeny Bazalar-Montoya, Nora Urraca, Alejandra Salguero, Samuel Wiafe, Romina Foster-Bonds, Erin Royer, Michelle Gallas, Pilar Magoulas, Adeline Vanderver, Marwan Shinawi, Alan Taylor, Kristen Fishler, Duncan Henry, Daria Salyakina, Kate Gibson, Melissa Lah, Alka Malhotra, James Avecilla, Andrew Warren, Denise Perry, Max Arseneault   +37 more
doaj   +1 more source

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

P761: Calculating maternal polygenic risk scores from prenatal screening by cell-free DNA data*

Genetics in Medicine Open
Sung Kim, Victoria Corey, Mauro Chavez, Layla Qasim, Cosmin Deciu, Angela Henry, Salome Bagayan, Sasha Treadup, Mike Mehan, Eileen de Feo   +9 more
doaj   +1 more source

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

Advanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji, Ruichen Zhang, Dongyi Xu, Patrick C. A. van der Wel, Alessia Lasorsa, Guotai Li, Fangze Guo, Qihui Zhou, Patrick van Rijn   +8 more
wiley   +1 more source

P698: Accurate genotyping of high homology HBA and SMN genes from whole exome sequencing

Genetics in Medicine Open
Ashley Carroll, Jon Albay, Dianne Hernandez, Jonathan Nery, Susanne Angelow, Aaron Halpern, Kingshuk Mukherjee, Eric Roller, Vitor Onuchic, James Han   +9 more
doaj   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

P412: An atypical case of pseudohypoparathyroidism 1b due to uniparental hetero- and isodisomy detected by genome sequencing

Genetics in Medicine Open
Joshua Lowry, Zinayida Schlachetzki, Brendan Burns, Ajay Varadarajan, Brittany Thomas, Richard Wang, Evgenii Chekalin, Jon Albay, Marwan Shinawi, Dorothy Grange, Ryan Taft, Denise Perry, Akanchha Kesari   +12 more
doaj   +1 more source

Optimized library preparation, sequencing, and data analysis protocols for the generation of orbivirus consensus sequences. [PDF]

BMC Genomics
Dunham TJ, Sherman TJ, Reed KJ, Brelsfoard C, Anderson TK, Cohnstaedt LW, Stenglein MD, Mayo CE.   +7 more
europepmc   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

A bench-to-data analysis workflow for respiratory syncytial virus whole-genome sequencing with short and long-read approaches. [PDF]

Genome Med
Gómez-Del Rosario A, Muñoz-Barrera A, Alcoba-Florez J, García-Martínez de Artola D, Rodríguez-García N, Lorenzo-Salazar JM, González-Montelongo R, Flores C, Ciuffreda L.   +8 more
europepmc   +1 more source