Results 111 to 120 of about 173,111 (241)

Artificial real metagenomic reads

<p>We created Nanopore and Illumina metagenomic datasets by combining real (non-simulated) sequencing reads into an artificial metagenomic dataset.
Hall, Michael B.
core   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

The complete mitogenome dataset of Hasora Schoenherr (Latreille, 1824) (Lepidoptera: Hesperiidae: Coeliadinae) from MalaysiaMendeley Data

Data in Brief
Hasora schoenherr is a Hesperiidae species belonging to the subfamily Coeliadinae. Here, we report the complete mitogenome dataset of Hasora schoenherr sampled from Endau-Rompin Johor National Park, Malaysia, sequenced using the Illumina NovaSeq 6000 ...
Lam Boon Hui, Marylin Miga, Chan Vei Siang, Aqilah Awg Abdul Rahman, Sivachandran Parimannan, Heera Rajandas, Frankie Thomas Sitam, Lili Tokiman, Jai Kemalok, Mohd Shahir Shamsir, Faezah Mohd Salleh   +10 more
doaj   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Complete chloroplast genome data of Isatis indigotica Fort, an important medicinal plant species

Data in Brief
Isatis indigotica Fort. is a biennial herbaceous plant belonging to the Isatis genus of the Brassicaceae family, with significant medicinal value. The entire genome of the chloroplast of Isatis indigotica was sequenced using the Illumina high-throughput ...
Chi Liu, Lingyang Kong, Shan Jiang, Meitong Pan, Lengleng Ma, Junbai Ma, Wei Ma, Xiubo Liu   +7 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Human Epigenome analysis by CHIP-Seq

, 2009
1
노태영
core  

Single-cell RNA sequencing data on primary samples from: Aberrant expression of SLAMF6 constitutes a targetable immune escape mechanism in acute myeloid leukemia

This dataset includes single-cell RNA sequencing (scRNA-seq) data from primary AML (acute myeloid leukemia) samples. Libraries were produced using the 10X Genomics Chromium Single Cell 3ʹ Reagent Kits v3 and sequenced on an Illumina Novaseq 6000 system ...
Thoas Fioretos, Carl Sandén, https://orcid.org/   +2 more
core   +1 more source

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source