Results 131 to 140 of about 666,692 (334)
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Visual Concept-driven Image Generation with Text-to-Image Diffusion Model [PDF]
arXivText-to-image (TTI) diffusion models have demonstrated impressive results in generating high-resolution images of complex and imaginative scenes. Recent approaches have further extended these methods with personalization techniques that allow them to integrate user-illustrated concepts (e.g., the user him/herself) using a few sample image illustrations.
arxiv
Illustrations of the Orthopaedic Apparatus, Referred to at a Demonstration of Modern Orthopaedic Methods [PDF]
, 1888 Neil Smith
openalex +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
REHMLAC, 2009 This work shows the way in which Freemasonry in Perpignan, a French city bordered by Barcelona, was inserted into the network of various forms of sociability during the Enlightenment.
Céline Sala
doaj
II.—On the Spongia coriacea of Montagu,=Leucosolenia coriacea, Bk., together with a new variety of Leucosolenia lacunosa, Bk., elucidating the spicular structure of some of the fossil Calcispongiæ; followed by illustrations of the pin-like spicules on Verticillites helvetica, De Loriol [PDF]
, 1884 H.J. Carter
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Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.We provide a step‐by‐step guide for producing E140 antigen fragments from Plasmodium berghei (Pb1) and Plasmodium vivax (Pv1). Pb1/Pv1 are expressed in E. coli, solubilized by freeze–thawing, refolded by slow dilution, purified by affinity chromatography (IMAC), then concentrated and subjected to quality control.
Rodolfo Ferreira Marques +5 more
wiley +1 more source