Results 51 to 60 of about 677,734 (335)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Visual explicitation in intersemiotic translation

open access: yesStridon, 2021
In Translation Studies, explicitation generally refers to an interlingual process where something that is implicit in the source text is made explicit in the target text.
Anne Ketola
doaj   +1 more source

Inspire creativity with ORIBA: Transform Artists' Original Characters into Chatbots through Large Language Model [PDF]

open access: yesarXiv, 2023
This research delves into the intersection of illustration art and artificial intelligence (AI), focusing on how illustrators engage with AI agents that embody their original characters (OCs). We introduce 'ORIBA', a customizable AI chatbot that enables illustrators to converse with their OCs.
arxiv  

Phase Transitions of Cellular Automata [PDF]

open access: yesP.-Y. Louis and F.R. Nardi (eds.), Probabilistic Cellular Automata, Emergence, Complexity and Computation 27, Springer 2018, 2014
We explore some aspects of phase transitions in cellular automata. We start recalling the standard formulation of statistical mechanics of discrete systems (Ising model), illustrating the Monte Carlo approach as Markov chains and stochastic processes. We then formulate the cellular automaton problem using simple models, and illustrate different types ...
arxiv   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Cultural Identity in Children's Literature Book with Entrance of Native Elements in Illustration (Case Study: Works of Parviz Kalantary) [PDF]

open access: yesJilvah-i hunar, 2017
1960's were one of important eras affecting Iranian art and culture. It was during these years when artists, writers and intellects tried to find a national-religious identity in their worksdue to illuminations of the age which insisted on going back to ...
adeleh rafaee, parisa shad
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

open access: yesFEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring   +6 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

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