Results 101 to 110 of about 991,933 (306)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Least squares estimation for the subcritical Heston model based on continuous time observations [PDF]

open access: yes, 2018
We prove strong consistency and asymptotic normality of least squares estimators for the subcritical Heston model based on continuous time observations. We also present some numerical illustrations of our results.Comment: 22 pages. arXiv admin note: text
Barczy, Matyas, Nyul, Balazs, Pap, Gyula
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Le genre féerique illustré à l’époque victorienne : splendeurs et déclin d’un genre entré en résistance

open access: yesCahiers Victoriens et Edouardiens, 2012
After having been blacklisted for decades, fairy tales unexpectedly came back into favour in Great Britain during the Victorian period, being staunchly supported by authors like Ruskin, Dickens or MacDonald.
Audrey Doussot
doaj   +1 more source

Two new species of the genus Pahamunaya Schmid (Trichoptera: Polycentropodidae) from Vietnam [PDF]

open access: yes, 2012
Two new species of the genus Pahamunaya Schmid (Trichoptera: Polycentropodidae), P. talon sp. n. and P. spinifera sp. n., from Vietnam are described and illustrated. Examination of the holotype male of P.
Arefina-Armitage, Tatiana I.   +1 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

High pressure liquid gas pump [PDF]

open access: yes, 1972
Design and development of two types of pumps for handling liquefied gases are discussed. One pump uses mechanical valve shift and other uses pneumatic valve shift.
Acres, R. L.
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Fatimid Secular Architecture: a Visual Reconstruction

open access: yesPad, 2019
The Fatimid dynasty was established in the Tenth century in what is modern day Tunis. Their capital was founded in the city of Al-Mahdya from which they expand- ed their realm to encompass North Africa and Egypt.
Ahmed Wahby, Mona A. Marie
doaj  

West Indian species of Beameromyia Martin (Diptera: Asilidae) [PDF]

open access: yes, 2011
The West Indian species of Beameromyia Martin are reviewed. Four new species are described, and Beameromyia insulara Martin and B. cubensis (Bigot) are redescribed.
Scarbrough, Aubrey G.
core  

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