Results 71 to 80 of about 1,314 (191)

Dexamethasone Provides Effective Immunosuppression for Improved Survival of Retinal Organoids after Epiretinal Transplantation

Stem Cells International, Volume 2019, Issue 1, 2019., 2019
We investigated the efficacy of the immunosuppressants rapamycin (RAP) and dexamethasone (DEX) in improving the survival of retinal organoids after epiretinal transplantation. We first compared the immunosuppressive abilities of DEX and RAP in activated microglia in an in vitro setting.
Bikun Xian, Ziming Luo, Kaijing Li, Kang Li, Mingjun Tang, Runcai Yang, Shoutao Lu, Haijun Zhang, Jian Ge, Jason S. Meyer   +9 more
wiley   +1 more source

Current Advances in Pharmacotherapy and Technology for Diabetic Retinopathy: A Systematic Review

Journal of Ophthalmology, Volume 2018, Issue 1, 2018., 2018
Diabetic retinopathy (DR) is classically defined by its vascular lesions and damage in the neurons of the retina. The cellular and clinical elements of DR have many features of chronic inflammation. Understanding the individual cell‐specific inflammatory changes in the retina may lead to novel therapeutic approaches to prevent vision loss.
Lei Lu, Ying Jiang, Ravindran Jaganathan, Yanli Hao, Hyeong Gon Yu   +4 more
wiley   +1 more source

Clinical-Decision Criteria to Identify Recurrent Diabetic Macular Edema Patients Suitable for Fluocinolone Acetonide Implant Therapy (ILUVIEN®) and Follow-Up Considerations/Recommendations

Clinical Ophthalmology, 2020
Alfredo Adán,1 Francisco Cabrera,2 Marta S Figueroa,3 Enrique Cervera,4 Francisco J Ascaso,5 Patricia Udaondo,6 Maximino Abraldes,7 Miguel Ángel Reyes,8 Marta Pazos,1 Bernardete Pessoa,9 Félix Armadá10 1Hospital Clínic ...
Adán A, Cabrera F, Figueroa MS, Cervera E, Ascaso FJ, Udaondo P, Abraldes M, Reyes MÁ, Pazos M, Pessoa B, Armadá F   +10 more
doaj  

Imaging, quantitation and kinetic modelling of intravitreal nanomaterials [PDF]

, 2022
In this study, the intravitreal pharmacokinetics of nanomaterials were investigated in vivo in rats and rabbits. Impact of particle size and shape (spherical, longitudinal) on ocular particle distribution and elimination was investigated with fundus ...
Cao, Shoupeng, Lajunen, Tatu, Puranen, Jooseppi, Ranta, Veli-Pekka, Ridolfo, Roxane, Ruponen, Marika, Sadeghi, Amir, Tavakoli, Shirin, Toropainen, Elisa, Urtti, Arto, van Hest, Jan   +10 more
core   +2 more sources

The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy

Oxidative Medicine and Cellular Longevity, Volume 2018, Issue 1, 2018., 2018
Diabetic retinopathy is one of the most serious microvascular complications induced by hyperglycemia via five major pathways, including polyol, hexosamine, protein kinase C, and angiotensin II pathways and the accumulation of advanced glycation end products.
Meng-Yu Wu, Giou-Teng Yiang, Tzu-Ting Lai, Chia-Jung Li, Joanna Lecka   +4 more
wiley   +1 more source

Ocular Complications of Diabetes and Therapeutic Approaches

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
Diabetes mellitus (DM) is a metabolic disease defined by elevated blood glucose (BG). DM is a global epidemic and the prevalence is anticipated to continue to increase. The ocular complications of DM negatively impact the quality of life and carry an extremely high economic burden.
Victoria J. Vieira-Potter, Dimitrios Karamichos, Darren J. Lee, Ciro Costagliola   +3 more
wiley   +1 more source

Case Series Investigating the Efficacy and Safety of Bilateral Fluocinolone Acetonide (ILUVIEN®) in Patients with Diabetic Macular Edema [PDF]

Ophthalmology and Therapy, 2016
Patients with diabetic macular edema (DME), a chronic, vision-limiting condition, may be insufficiently responsive to standard-of-care anti-vascular endothelial growth factor (VEGF) and/or laser therapies. One approved treatment for such patients is 0.2 μg/day fluocinolone acetonide (FAc) sustained-release implant; however, data are limited for ...
Elaraoud, Ibrahim, Attawan, Alaa, Quhill, Fahd   +2 more
openaire   +4 more sources

Elevated Intraocular Pressure After Intravitreal Steroid Injection in Diabetic Macular Edema: Monitoring and Management [PDF]

, 2016
INTRODUCTION: With the increasing use of intravitreal administration of corticosteroids in macular edema, steroid-induced intraocular pressure (IOP) rise is becoming an emergent issue.
Denis, P, Diestelhorst, M, Figueiredo, AR, Garway-Heath, DF, Goñi, FJ, Nordmann, J-P, Stalmans, I, Taylor, S   +7 more
core  

Clinical utility of intravitreal fluocinolone acetonide (Iluvien®) implant in the management of patients with chronic diabetic macular edema:a review of the current literature [PDF]

, 2017
The first-line therapy for patients with center-involving diabetic macular edema (DME) is with intravitreal anti-vascular endothelial growth factor (VEGF) agents, with or without adjunctive macular laser treatment.
Anand, Astha, Saedon, Habiba, Yit, Yang C.   +2 more
core   +2 more sources

Real-life results after the administration of a single 0.19 mg fluocinolone acetonide (ILUVIEN®) implant in patients with refractory diabetic macular edema.

Ophthalmic Research
INTRODUCTION Real-life data on the functional and anatomical outcome of intravitreal fluocinolone acetonide (FAc) in patients with refractory diabetic macular edema (DME).
Warda Darwisch, Maria della Volpe-Waizel, P. K. Roberts, K. Boden, P. Szurman, Annekatrin Rickmann   +5 more
semanticscholar   +1 more source