Results 81 to 90 of about 1,314 (191)

A Novel Technique for Repositioning of a Migrated ILUVIEN® (Fluocinolone Acetonide) Implant into the Anterior Chamber [PDF]

Ophthalmology and Therapy, 2015
Fluocinolone acetonide (FAc) intravitreal implant (ILUVIEN(®); Alimera Sciences Limited, Aldershot, UK) has been approved in the UK for the treatment of chronic diabetic macula edema, insufficiently responsive to available therapies. It is inserted into the vitreous cavity through a 25-gauge needle. Migration of the implant to the anterior chamber (AC)
El-Ghrably, Ibraheem A., Saad, Ahmed, Dinah, Christiana   +2 more
openaire   +2 more sources

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source

Investigation of Diffusion Characteristics through Microfluidic Channels for Passive Drug Delivery Applications

Journal of Drug Delivery, Volume 2016, Issue 1, 2016., 2016
Microfluidics has many drug delivery applications due to the ability to easily create complex device designs with feature sizes reaching down to the 10s of microns. In this work, three different microchannel designs for an implantable device are investigated for treatment of ocular diseases such as glaucoma, age‐related macular degeneration (AMD), and ...
Marcus J. Goudie, Alyssa P. Ghuman, Stephanie B. Collins, Ramana M. Pidaparti, Hitesh Handa, Viness Pillay   +5 more
wiley   +1 more source

The Port Delivery System with ranibizumab: a new paradigm for long-acting retinal drug delivery. [PDF]

, 2022
The Port Delivery System with ranibizumab (PDS) is an innovative intraocular drug delivery system designed for the continuous delivery of ranibizumab into the vitreous for 6 months and beyond.
Barteselli, Giulio, Grace, Lori, Hieb, Aaron, Horvath, Judit, Jia, Weitao, Ranade, Shrirang, Rea, Jennifer, Stewart, Jay, Tam, Tammy, Wieland, Mark   +9 more
core   +1 more source

Stimuli‐responsive systems: A focus on controlled drug delivery for posterior segment ocular disease

Responsive Materials, Volume 3, Issue 4, November 2025.
This review highlights recent advances in stimuli‐responsive drug delivery for posterior segment diseases, focusing on mechanisms and potential. It also explores mechanically interlocked molecules and bioorthogonal reactions as novel approaches. Challenges and future perspectives are discussed, aiming to bridge the gap between research and clinical ...
Chengzhi Zhang, Jiayi Hou, Yameng Zhao, Yiwen Wang, Kexin Wang, Siyu Li, Yange Wang, Jiehao Zhang, Shenao Ding, Chenxu Zhang, Zongming Song, Ye Tao   +11 more
wiley   +1 more source

Twelve‐Month Follow‐Up of Dexamethasone Implants for Macular Edema from Various Diseases in Vitrectomized and Nonvitrectomized Eyes

Journal of Ophthalmology, Volume 2016, Issue 1, 2016., 2016
Purpose. To evaluate the best‐corrected visual acuity (BCVA), central retinal thickness (CRT), and the number of dexamethasone implants needed to treat cystoid macular edema (CME) from various etiologies over 12 months in vitrectomized and nonvitrectomized eyes. Methods.
Eduardo A. Novais, Mauricio Maia, Paulo Augusto de Arruda Mello Filho, João Rafael de Oliveira Dias, José Maurício B. B. Garcia, Gabriel C. de Andrade, Ricardo N. Louzada, Marcos Ávila, André Maia, J. Fernando Arevalo, Lihteh Wu, Maria Berrocal, Emmerson Badaró, Michel Farah, Enrico Peiretti   +14 more
wiley   +1 more source

Three-year results from the Retro-IDEAL study: Real-world data from diabetic macular edema (DME) patients treated with ILUVIEN® (0.19 mg fluocinolone acetonide implant)

European Journal of Ophthalmology, 2019
Introduction: The Retro-IDEAL (ILUVIEN Implant for chronic DiabEtic MAcuLar edema) study is a retrospective study designed to assess real-world outcomes achieved with the ILUVIEN® (0.19 mg fluocinolone acetonide (FAc)) in patients with chronic diabetic ...
A. Augustin, S. Bopp, M. Fechner, F. Holz, D. Sandner, A. Winkgen, R. Khoramnia, T. Neuhann, Marcus Warscher, M. Spitzer, W. Sekundo, B. Seitz, T. Duncker, Christian Ksinsik, H. Höh, Daniela Gentsch   +15 more
semanticscholar   +1 more source

Challenging Clinical Cases – A Walk Through Supplemental Therapy with Intravitreal Ranibizumab Therapy Following Treatment of Diabetic Macular Edema with the 0.19 mg Fluocinolone Acetonide Implant (ILUVIEN®)

International Medical Case Reports Journal, 2020
Purpose There are limited published data regarding the use of supplemental intravitreal therapies in patients with diabetic macular edema (DME) following treatment with the 0.19 mg fluocinolone acetonide (FAc; ILUVIEN®) intravitreal implant.
B. Pessoa, J. Melo-Beirão, A. Meireles, P. Menéres   +3 more
semanticscholar   +1 more source

A review on polymers in ocular drug delivery systems

MedComm – Biomaterials and Applications, Volume 3, Issue 2, June 2024.
Polymers play a pivotal role in ocular drug delivery, revolutionizing treatment approaches. These biomaterials enable controlled and sustained drug release at the targeted site, enhancing bioavailability and patient compliance. From nanosized particle‐based formulations to in situ gelation mechanisms, polymers offer improved treatment options for a ...
Amol C. Bisen, Arpon Biswas, Ayush Dubey, Sachin N. Sanap, Sristi Agrawal, Karan S. Yadav, Vaishali Singh, Priyanka Rawat, Sudhanshu Sagar, Madhav N. Mugale, Rabi S. Bhatta   +10 more
wiley   +1 more source

Comparison of In Vivo Gene Expression Profiling of RPE/Choroid following Intravitreal Injection of Dexamethasone and Triamcinolone Acetonide

Journal of Ophthalmology, Volume 2016, Issue 1, 2016., 2016
Purpose. To identify retinal pigment epithelium (RPE)/choroid genes and their relevant expression pathways affected by intravitreal injections of dexamethasone and triamcinolone acetonide in mice at clinically relevant time points for patient care. Methods. Differential gene expression of over 34,000 well‐characterized mouse genes in the RPE/choroid of
Zeljka Smit-McBride, Elad Moisseiev, Sara P. Modjtahedi, David G. Telander, Leonard M. Hjelmeland, Lawrence S. Morse, Tamer A. Macky   +6 more
wiley   +1 more source