Results 51 to 60 of about 159,380 (307)

OCT-Derived Radiomic Features Predict Anti–VEGF Response and Durability in Neovascular Age-Related Macular Degeneration

Ophthalmology Science, 2022
Purpose: No established biomarkers currently exist for therapeutic efficacy and durability of anti–VEGF therapy in neovascular age-related macular degeneration (nAMD). This study evaluated radiomic-based quantitative OCT biomarkers that may be predictive
Sudeshna Sil Kar, PhD, Hasan Cetin, MD, Leina Lunasco, BA, Thuy K. Le, BA, Robert Zahid, PharmD, Xiangyi Meng, PhD, Sunil K. Srivastava, MD, Anant Madabhushi, PhD, Justis P. Ehlers, MD   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Automatic segmentation and classification of breast lesions through identification of informative multiparametric PET/MRI features

European Radiology Experimental, 2019
Background Multiparametric positron emission tomography/magnetic resonance imaging (mpPET/MRI) shows clinical potential for detection and classification of breast lesions.
Wolf-Dieter Vogl, Katja Pinker, Thomas H. Helbich, Hubert Bickel, Günther Grabner, Wolfgang Bogner, Stephan Gruber, Zsuzsanna Bago-Horvath, Peter Dubsky, Georg Langs   +9 more
doaj   +1 more source

Feeling like me again : a grounded theory of the role of breast reconstruction surgery in self-image

, 2013
The present study aimed to develop a theoretical understanding of the role of breast reconstruction in women's self-image. Semi-structured interviews were conducted with 10 women from breast cancer support groups who had undergone breast reconstruction ...
Mckean, Lindsay N., Mackean, L, Newman, Emily; id_orcid, McKean, Lindsay, Newman, E, Adair, Pauline, Newman, Emily F., Adair, Pauline; id_orcid   +7 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Clinical GBM hybrid artificial intelligence for prescription dose recommendation and outcome prediction after gamma knife radiosurgery treatment: a proof-of-concept

Frontiers in Oncology
BackgroundOutcomes after Gamma Knife radiosurgery (GKRS) for recurrent glioblastoma (GBM) are heterogeneous, and prescription dose selection remains challenging in previously irradiated brain.
Jheremy S. Reyes, Jheremy S. Reyes, Alexandros Bouras, Alexandros Bouras, Ajay Niranjan, Ajay Niranjan, L Dade Lunsford, Constantinos G. Hadjipanayis, Constantinos G. Hadjipanayis   +8 more
doaj   +1 more source

Image-Guided Otorhinolaryngology

, 2013
Beginning with a brief historical background, the chapter then offers the reader a practical overview of established procedures using image-guided surgery (IGS) in otorhinolaryngology.
Dubach, Patrick, Caversaccio, Marco, Marco Caversaccio, Weber, Stefan, Brett Bell, Stefan Weber, Bell, Brett, Patrick Dubach   +7 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Safety and image quality of cardiovascular magnetic resonance imaging in patients with retained epicardial pacing wires after heart transplantation

Journal of Cardiovascular Magnetic Resonance, 2021
Background Temporary epicardial pacing wires, implemented in patients during heart transplantation, are routinely removed before discharge. However, in some cases, these wires may remain in situ and are often considered as a contraindication for ...
Constantin Gatterer, Marie-Elisabeth Stelzmüller, Andreas Kammerlander, Andreas Zuckermann, Martin Krššák, Christian Loewe, Dietrich Beitzke   +6 more
doaj   +1 more source