Results 61 to 70 of about 159,380 (307)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Robot-assisted image-guided transcranial magnetic stimulation for somatotopic mapping of the motor cortex: a clinical pilot study.

, 2009
Shape and exact location of motor cortical areas varies among individuals. The exact knowledge of these locations is crucial for planning of neurosurgical procedures.
Paulus, Walter J., Paulus, W, Schweikard, Achim, Giese, A, Fadini, T, Schweikard, A, Bockermann, Volker, Bockermann, V, Achim Schweikard, Finke, Markus, Markus Finke, Tommaso Fadini, Kai Kallenberg, Walter Paulus, Alf Giese, Siemerkus, J, Jakob Siemerkus, Volker Bockermann, Rohde, Veit, Kallenberg, Kai, Veit Rohde, Kantelhardt, SR, Rohde, V, Sven Rainer Kantelhardt, Matthaeus, Lars, Matthaeus, L, Kantelhardt, Sven Rainer, Lars Matthaeus, Fadini, Tommaso, Siemerkus, Jakob, Giese, Alf, Finke, M, Kallenberg, K   +32 more
core   +1 more source

Augmented reality for image guidance in transoral robotic surgery

, 2020
With the advent of precision surgery, there have been attempts to integrate imaging with robotic systems to guide sound oncologic surgical resections while preserving critical structures.
Holsinger, FC, Azizian, M, Tsang, RKY, Chan, JYK, Liu, S, Sorger, JM   +5 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Physics inspired neural network for optical property retrieval from diffuse reflectance

Frontiers in Photonics
IntroductionOptical property retrieval in diffuse reflectance imaging, like diffuse reflectance spectroscopy (DRS) and hyperspectral imaging (HSI), often involves fitting measured spectra to analytical solutions using approximations such as Diffusion ...
Mark Witteveen, Mark Witteveen, Tiziano Natali, Tiziano Natali, Theo J. M. Ruers, Theo J. M. Ruers, Behdad Dashtbozorg   +6 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Point Projection Mapping System for Tracking, Registering, Labeling, and Validating Optical Tissue Measurements

Journal of Imaging
The validation of newly developed optical tissue-sensing techniques for tumor detection during cancer surgery requires an accurate correlation with the histological results. Additionally, such an accurate correlation facilitates precise data labeling for
Lianne Feenstra, Stefan D. van der Stel, Marcos Da Silva Guimaraes, Behdad Dashtbozorg, Theo J. M. Ruers   +4 more
doaj   +1 more source

Prospective Techniques for Magnetic Resonance Imaging–Guided Robot-Assisted Stereotactic Neurosurgery

, 2020
Stereotactic neurosurgery involves a technique that can locate the brain targets using an external coordinate system. With the advancements of magnetic resonance imaging (MRI), numerous studies on frameless stereotaxy and MRI-guided/verified technique ...
Poon, WS, Su, H, Kwok, KW, Chan, DTM, Leong, CWM, Guo, Z   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Intraoperative ureter identification with a novel fluorescent catheter

Scientific Reports, 2021
Iatrogenic ureteral injuries (IUI) occur in 0.5–1.3% of cases during abdominal surgery. If not recognized intraoperatively, IUI increase morbidity/mortality. A universally accepted method to prevent IUI is lacking. Near-infrared fluorescent imaging (NIRF)
Manuel Barberio, Mahdi Al-Taher, Eric Felli, Anila Hoskere Ashoka, Jacques Marescaux, Andrey Klymchenko, Michele Diana   +6 more
doaj   +1 more source