Results 71 to 80 of about 1,186,551 (242)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Unpaired Image-to-Image Translation with Diffusion Adversarial Network

Mathematics
Unpaired image translation with feature-level constraints presents significant challenges, including unstable network training and low diversity in generated tasks. This limitation is typically attributed to the following situations: 1.
Hangyao Tu, Zheng Wang, Yanwei Zhao
doaj   +1 more source

Facial expression morphing: enhancing visual fidelity and preserving facial details in CycleGAN-based expression synthesis [PDF]

PeerJ Computer Science
Recent advancements in facial expression synthesis using deep learning, particularly with Cycle-Consistent Adversarial Networks (CycleGAN), have led to impressive results.
Chayanon Sub-r-pa, Rung-Ching Chen, Ming-Zhong Fan   +2 more
doaj   +2 more sources

Applying a Pix2Pix Generative Adversarial Network to a Fourier-Domain Optical Coherence Tomography System for Artifact Elimination

IEEE Access, 2021
The presence of artifacts, including conjugate, DC, and auto-correlation artifacts, is a critical limitation of Fourier-domain optical coherence tomography (FD-OCT).
Chun-Ming Huang, Eddy Wijanto, Hsu-Chih Cheng   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Photogenic Guided Image-to-Image Translation With Single Encoder

IEEE Open Journal of the Computer Society
Image-to-image translation involves combining content and style from different images to generate new images. This technology is particularly valuable for exploring artistic aspects, such as how artists from different eras would depict scenes.
Rina Oh, T. Gonsalves
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Metalens-style image synthesis for metalens imaging via image-to-image translation

Scientific Reports
Metalenses offer wafer-scale, ultra-thin optics for compact cameras, but strong chromatic and field-dependent aberrations still limit their practical use.
Chanik Kang, Hyewon Suk, Joonhyuk Seo, Ikbeom Jang, Haejun Chung   +4 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source