Results 131 to 140 of about 13,865,362 (341)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

3D imaging of Sox2 enhancer clusters in embryonic stem cells

, 2014
Zhe Liu, Wesley R. Legant, Bi‐Chang Chen, Li Li, Jonathan B. Grimm, Luke D. Lavis, Eric Betzig, Robert Tjian   +7 more
openalex   +2 more sources

An Eccentric Massive Jupiter Orbiting a Subgiant on a 9.5-day Period Discovered in the Transiting Exoplanet Survey Satellite Full Frame Images [PDF]

, 2019
Joseph E. Rodriguez, Samuel N. Quinn, Chelsea X. Huang, Andrew Vanderburg, Kaloyan Penev, Rafael Brahm, Andrés Jordán, Mma Ikwut-Ukwa, Shelly Tsirulik, David W. Latham, Keivan G. Stassun, Avi Shporer, Carl Ziegler, Elisabeth Matthews, Jason D. Eastman, B. Scott Gaudi, Karen A. Collins, Natalia Guerrero, Howard M. Relles, Thomas Barclay, Natalie M. Batalha, Perry Berlind, Allyson Bieryla, L. G. Bouma, Patricia T. Boyd, Jennifer Burt, Michael L. Calkins, Jessie Christiansen, David R. Ciardi, Knicole D. Colón, Dennis M. Conti, Ian J. M. Crossfield, Tansu Daylan, Jason Dittmann, Diana Dragomir, Scott Dynes, Néstor Espinoza, Gilbert A. Esquerdo, Zahra Essack, Aylin Garcia Soto, Ana Glidden, Maximilian N. Günther, Thomas Henning, Jon M. Jenkins, John F. Kielkopf, Akshata Krishnamurthy, Nicholas M. Law, Alan M. Levine, Pablo Lewin, Andrew W. Mann, Edward H. Morgan, Robert L. Morris, Ryan J. Oelkers, Martin Paegert, Joshua Pepper, Elisa V. Quintana, George R. Ricker, Pamela Rowden, Sara Seager, Paula Sarkis, Joshua E. Schlieder, Lizhou Sha, Andrei Tokovinin, Guillermo Torres, Roland K. Vanderspek, Steven Villanueva, Jesus Noel Villaseñor, Joshua N. Winn, Bill Wohler, Ian Wong, Daniel A. Yahalomi, Liang Yu, Zhuchang Zhan, George Zhou   +73 more
openalex   +1 more source

Sensing stress responses in potato with whole-plant redox imaging

, 2021
Matanel Hipsch, Nardy Lampl, Einat Zelinger, Orel Barda, Daniel Waiger, Shilo Rosenwasser   +5 more
openalex   +2 more sources

Images [PDF]

Canadian Journal of Anaesthesia, 1992
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Quantitative 3D Analysis of Plant Roots Growing in Soil Using Magnetic Resonance Imaging

, 2016
Dagmar van Dusschoten, Ralf Metzner, Johannes Kochs, Johannes A. Postma, Daniel Pflugfelder, Jonas Bühler, Ulrich Schurr, Siegfried Jahnke   +7 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Castration-Resistant Prostate Cancer Bone Metastasis Response Measured by ¹⁸F-Fluoride PET After Treatment with Dasatinib and Correlation with Progression-Free Survival: Results from American College of Radiology Imaging Network 6687 [PDF]

, 2015
Evan Y. Yu, Fenghai Duan, Mark Muzi, Xuan Deng, Bennett B. Chin, Joshi J. Alumkal, Mary-Ellen Taplin, Jina Taub, Ben Herman, Celestia S. Higano, Robert K. Doot, Donna Hartfeil, Philip G. Febbo, David A. Mankoff   +13 more
openalex   +1 more source

Dataset from fundus images for the study of diabetic retinopathy

, 2021
Verónica Elisa Castillo Benítez, Ingrid Castro Matto, Julio César Mello-Román, José Luis Vázquez Noguera, Miguel García-Torres, Jordan Ayala, Diego P. Pinto-Roa, Pedro E. Gardel-Sotomayor, Jacques Facon, Sebastián Alberto Grillo   +9 more
openalex   +1 more source