Results 141 to 150 of about 13,865,268 (312)
Large language models for causal hypothesis generation in science
Machine Learning: Science and TechnologyTowards the goal of understanding the causal structure underlying complex systems—such as the Earth, the climate, or the brain—integrating Large language models (LLMs) with data-driven and domain-expertise-driven approaches has the potential to become a ...
Kai-Hendrik Cohrs +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 2012 This image originally appeared in the 2012 Research student photography and image competition held to celebrate National Science Week (11-19 August)
Denny Thomas
core
, 2014 This paper considers the ontological significance of invisibility in relation to the question ‘what is a digital image?’ Its argument in a nutshell is that the emphasis on visibility comes at the expense of latency and is symptomatic of the style of ...
Rubinstein, Daniel
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
, 2012 This image originally appeared in the 2012 Research student photography and image competition held to celebrate National Science Week (11-19 August)
Veselin Boshkovikj
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Keep calm and carry on fellow PhD student
, 2012 This image originally appeared in the 2012 Research student photography and image competition held to celebrate National Science Week (11-19 August)
Mohammad Yarahmadi
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source