Results 241 to 250 of about 242,521 (294)

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

FTO-mediated m⁶A demethylation of BCL6 promotes gastric cancer progression by suppressing ferroptosis. [PDF]

RNA Biol
Wang Y, Fan F, Zhan Z, Yu C, Chen S.
europepmc   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

<i>Lactobacillus johnsonii</i>-Derived Extracellular Vesicles Ameliorate Alcohol-Exacerbated Experimental Autoimmune Prostatitis by Inhibiting M1 Macrophage Polarization. [PDF]

Int J Nanomedicine
Zhu Q, Liu Y, Hu W, Liu Y, Fu S, Xie W, Liu J, Xiong Y, Sun T, Gong B.   +9 more
europepmc   +1 more source

CD71-Targeted and ROS-Responsive Micelles for Homoharringtonine Delivery to Enhance Therapeutic Efficiency Against FLT3-ITD Acute Myeloid Leukemia. [PDF]

Int J Nanomedicine
Tang Y, Li J, Ye W, Du Y, Zhang Y, Yang Y, Ye Y, Gong Y.   +7 more
europepmc   +1 more source

Identifying Donor Immune Cells in the Intestinal Mucosa of Chimeric Recipient Mice by Immunofluorescence. [PDF]

Curr Protoc
Canale V, Asiedu S, Malki F, Chen G, Nair MG, McCole DF.   +5 more
europepmc   +1 more source

Prussian Blue Nanozyme Potentiates Venetoclax Efficacy in Acute Myeloid Leukemia by Inducing a More Mature Phenotype. [PDF]

Int J Nanomedicine
Yang F, Wu H, Yao J, Peng X, Yang A, Wen T, Meng J, Liu J, Zhang Y, Wang T, Xu H.   +10 more
europepmc   +1 more source

Biomimetic M1 Macrophage Membrane-Camouflaged Nanoplatform Remodels Tumor Microenvironment for Enhanced Antitumor Immunity. [PDF]

Int J Nanomedicine
Bai X, Han X, Wang W, Wang N, Li L, Hu J, Zhang Q, Qian X.   +7 more
europepmc   +1 more source

Mapping Immunity With Cutting-Edge Spatial Biology and Tissue Cytometry Innovations. [PDF]

MedComm (2020)
Cárdenas-Piedra L, Samuel SG, Mungenast F, Yasothkumar D, Ecker RC, Batra J.   +5 more
europepmc   +1 more source