Results 101 to 110 of about 13,295,115 (295)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Ontologies to interpret remote sensing images: why do we need them?

GIScience & Remote Sensing, 2019
The development of new sensors and easier access to remote sensing data are significantly transforming both the theory and practice of remote sensing. Although data-driven approaches based on innovative algorithms and enhanced computing capacities are ...
Damien Arvor, Mariana Belgiu, Zoe Falomir, Isabelle Mougenot, Laurent Durieux   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Image to interpretation

, 2002
The ink and stylus tablets discovered at the Roman Fort of Vindolanda have provided a unique resource for scholars of ancient history. However, the stylus tablets in particular have proved extremely difficult to read. The aim of this thesis is to explore the extent to which techniques from Artificial Intelligence can be used to develop a system that ...
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Dermoscopic Image Digital Post-Processing Perception and Use Among Members of theInternational Dermoscopy Society: Results of a Web-based Survey

Dermatology Practical & Conceptual
Introduction: Speculatively, digital image post-processing (DIPP) enhances diagnostic accuracy in dermoscopy. Objective: We aimed to investigate the advantages and limitations of DIPP, as well as its perceived reliability and safety.
Marian Voloshynovych, Paweł Pietkiewicz , Cristián Navarette-Dechent , Aimilios Lallas , John Paoli , Harald Kittler , Ashfaq A. Marghoob, Mohamad Goldust, Jacek C. Szepietowski , Iris Zalaudek , Thomas M. Beachkofsky, Caterina Longo , Cliff Rosendahl , Norbert Kiss, Giuseppe Argenziano, Mohammad Jafferany, Agnieszka Leszczyńska-Pietkiewicz, Natalia Salwowska, Nataliia Matkovska   +18 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Deep Learning-Based Semantic Segmentation and Classification of Otoscopic Images for Otitis Media Diagnosis and Health Promotion

Diagnostics
Background/Objectives: Otitis media (OM), including acute otitis media (AOM) and chronic otitis media (COM), is a common middle ear disease that can lead to significant morbidity if not accurately diagnosed.
Chien-Yi Yang, Che-Jui Lee, Wen-Sen Lai, Kuan-Yu Chen, Chung-Feng Kuo, Chieh Hsing Liu, Shao-Cheng Liu   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Artificial Intelligence-Aided Tooth Detection and Segmentation on Pediatric Panoramic Radiographs in Mixed Dentition Using a Transfer Learning Approach

Diagnostics
Background/Objectives: Accurate identification of deciduous and permanent teeth on panoramic radiographs (PRs) during mixed dentition is fundamental for early detection of eruption disturbances, yet relies heavily on clinician experience due to ...
Serena Incerti Parenti, Giorgio Tsiotas, Alessandro Maglioni, Giulia Lamberti, Andrea Fiordelli, Davide Rossi, Luciano Bononi, Giulio Alessandri-Bonetti   +7 more
doaj   +1 more source