Results 41 to 50 of about 12,009,576 (309)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Application of borehole images in the characterization of volcanic paleoenvironments with implications for the exploration of hydrocarbons in Brazilian basins

Petroleum Exploration and Development
Conventional borehole image log interpretation of linear fractures on volcanic rocks, represented as sinusoids on unwrapped cylinder projections, is relatively straight-forward, however, interpreting non-linear rock structures and complex facies ...
S A FORNERO, J M MILLETT, C M DE JESUS, E F DE LIMA, G M MARINS, N F PEREIRA, L A BEVILAQUA   +6 more
doaj   +1 more source

Feature Point Matching Based on Distinct Wavelength Phase Congruency and Log-Gabor Filters in Infrared and Visible Images

Sensors, 2019
Infrared and visible image matching methods have been rising in popularity with the emergence of more kinds of sensors, which provide more applications in visual navigation, precision guidance, image fusion, and medical image analysis.
Xiaomin Liu, Jun-Bao Li, Jeng-Shyang Pan
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

LPSO: Multi-Source Image Matching Considering the Description of Local Phase Sharpness Orientation

IEEE Photonics Journal, 2022
To solve the matching problems caused by the large intensity difference between the multi-source images and the nonlinear radiation distortion, we present a multi-source image matching approach that considers the orientation of the phase sharpness. First,
Wei Yang, Chuan Xu, Liye Mei, Yongxiang Yao, Chang Liu   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Local Feature Extraction in Log-Polar Images

, 2015
We propose two different strategies to compute edges in the log-polar (cortical) domain. The space-variant processing is obtained by applying local operators (e.g. local derivative filters) directly on the log-polar images, or by embedding the same operators into the log-polar mapping, thus obtaining a cortical representation of the Cartesian features.
CHESSA, MANUELA, SOLARI, FABIO
openaire   +3 more sources

Log-log profiles of the ensemble-averaged MSD under different self-crowding conditions and CRO densities.

, 2018
The profile of variation in natural logarithm of the ratio of ensemble-averaged MSD to time,log (〈r2〉/t), with respect to the natural logarithm of time, log (t), is referred here as the log-log profile for simplicity. (A-G) Each plot demonstrates the log-
Rahul Gupta (358711)
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Log-log plots for crops yield in Somalia where the red line corresponds to the value of x_min in Table 7.

, 2023
Log-log plots for crops yield in Somalia where the red line corresponds to the value of xmin in Table 7.
Idika E. Okorie (11350612), Emmanuel Afuecheta (9454734), Saralees Nadarajah (776944)   +2 more
core   +1 more source