Results 51 to 60 of about 12,009,576 (309)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Benchmark of Neural Networks for Semantic Segmentation of Wood Log Ends

IEEE Access
Neural networks have achieved significant performance in image segmentation tasks. This paper describes a benchmark of deep learning-based methods for segmenting log ends of several species in images.
Dorian Martinetto, Georg Wimmer, Phuc Ngo, Frederic Mothe, Alexandre Piboule, Andreas Uhl, Isabelle Debled-Rennesson, Fleur Longuetaud   +7 more
doaj   +1 more source

Study of Three-Dimensional Digital Core Reconstruction Based on Multiple-Point Geostatistics in a Cylindrical Coordinate System

IEEE Access, 2019
Image inpainting and the extraction of different components from the electrical image log images are performed. After generating the training image, determining the appropriate template, multigrid, and event, calculating the conditional probability ...
Xiaoling Xiao, Xiang Zhang, Jing Zhang, Xiong Luo   +3 more
doaj   +1 more source

Log-log plots for crops yield in Uganda where the red line corresponds to the value of x_min in Table 7.

, 2023
Log-log plots for crops yield in Uganda where the red line corresponds to the value of xmin in Table 7.
Idika E. Okorie (11350612), Emmanuel Afuecheta (9454734), Saralees Nadarajah (776944)   +2 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Variational image registration using inhomogeneous regularization [PDF]

, 2014
We present a generalization of the convolution basedvariational image registration approach, in which differentregularizers can be implemented by conveniently exchangingthe convolution kernel, even if it is nonseparableor nonstationary.
Albrecht, Thomas, Schönborn, Sandro, Vetter, Thomas., Jud, Christoph, Lüthi, Marcel   +4 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Investigating the vertical and lateral heterogeneity in an Iranian carbonate reservoir using advanced petrophysical logs, petrographic data and image processing techniques

Journal of Petroleum Exploration and Production Technology
Carbonate formations, known for their complex characteristics, require detailed internal heterogeneity knowledge for effective exploration and production.
Saeed Yarmohammadi, Abdolrahim Javaherian, Mohammad Sharifi, Mohammad Reza Saberi, Hadi Mahdavi Basir   +4 more
doaj   +1 more source

Non-stationary log-periodogram regression [PDF]

, 1998
We study asymptotic properties of the log-periodogram semiparametric estimate of the memory parameter d for non-stationary (d>=1/2) time series with Gaussian increments, extending the results of Robinson (1995) for stationary and invertible Gaussian ...
Velasco Gómez, Carlos, Carlos Velasco, Velasco, Carlos   +2 more
core   +1 more source