Results 91 to 100 of about 22,968,084 (355)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Weighted Direct Nonlinear Regression for Effective Image Interpolation

IEEE Access, 2019
This paper proposes a learning-based image interpolation method based on weighted direct nonlinear regression. It attempts to learn the nonlinear relationship between the low-resolution patches and their corresponding high-resolution patches by using an ...
Jieying Zheng, Wanru Song, Yahong Wu, Feng Liu   +3 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Optical measurement of characteristics of thin films using a spiral zone plate

Компьютерная оптика
In this work we propose a method for measuring physical characteristics of thin samples (thin films), including thickness, refractive index and tilt by moving the observation plane.
A.G. Nalimov, E.S. Kozlova, S.S. Stafeev, V.V. Kotlyar, V.V. Podlipnov   +4 more
doaj   +1 more source

Image-Dehazing Method Based on the Fusion Coding of Contours and Colors

IEEE Access, 2019
The dehazing of images shot in fog is a hot spot in the study of computer vision. Unlike dehazing methods, which use an atmospheric scattering model, the method proposed here is based on fusion coding of contours and colors.
Mingming Tan, Tao Fang, Yingle Fan, Wei Wu, Qingshan She, Haitao Gan   +5 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Quantifying the Robustness of Vegetation Indices through Global Sensitivity Analysis of Homogeneous and Forest Leaf-Canopy Radiative Transfer Models

Remote Sensing, 2019
Vegetation indices (VIs) are widely used in optical remote sensing to estimate biophysical variables of vegetated surfaces. With the advent of spectroscopy technology, spectral bands can be combined in numerous ways to extract the desired information ...
Pablo Morcillo-Pallarés, Juan Pablo Rivera-Caicedo, Santiago Belda, Charlotte De Grave, Helena Burriel, Jose Moreno, Jochem Verrelst   +6 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Detection of elliptical polarization parameters using a metalens

Компьютерная оптика
A metalens capable of detecting the polarization ellipticity of an incident beam is considered in this paper. This metalens consists of blocks with diffraction gratings of a 140-nm height and a 220-nm period.
A.G. Nalimov, V.V. Kotlyar, A.A. Kovalev, S.D. Poletaev, Y.V. Khanenko   +4 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source