Results 91 to 100 of about 516,809 (278)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Effects of AI-Driven Face Restoration on Forensic Face Recognition

Applied Sciences
In biometric recognition, face recognition is a mature and widely used technique that provides a fast, accurate, and reliable method for human identification.
Mengxuan Yang, Shengnan Li, Jinhua Zeng
doaj   +1 more source

An In-Depth Survey of Underwater Image Enhancement and Restoration

IEEE Access, 2019
Images taken under water usually suffer from the problems of quality degradation, such as low contrast, blurring details, color deviations, non-uniform illumination, etc.
Miao Yang, Jintong Hu, Chongyi Li, Gustavo Rohde, Yixiang Du, Ke Hu   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Hybrid regularization inspired by total variation and deep denoiser prior for image restoration

Complex & Intelligent Systems
Image restoration is a fundamental problem in computer vision, with the goal of restoring high-quality images from degraded low-quality observation images. However, the ill-posedness of restoration problem often leads to artifacts in the results.
Hu Liang, Jiahao Zhang, Daisen Wei, Jinbo Zhu   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Structured FISTA for image restoration

Numerical Linear Algebra with Applications, 2019
SummaryIn this paper, we propose an efficient numerical scheme for solving some large‐scale ill‐posed linear inverse problems arising from image restoration. In order to accelerate the computation, two different hidden structures are exploited. First, the coefficient matrix is approximated as the sum of a small number of Kronecker products.
Zixuan Chen, James G. Nagy, Yuanzhe Xi, Bo Yu   +3 more
openaire   +3 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

MSTNet: a multi-stage progressive network with local–global transformer fusion for image restoration

Complex & Intelligent Systems
Image restoration is a challenging and complex problem involving recovering the original clear image from a degraded or noisy image. In the medical field, image restoration techniques can significantly improve the quality of endoscopic images, helping ...
Ruyu Liu, Lin Wang, Jie He, Jiajia Wang, Jianhua Zhang, Xiufeng Liu, Chaochao Wang, Haoyu Zhang, Sheng Dai   +8 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source