Results 61 to 70 of about 335,064 (318)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A comparative evaluation of interactive segmentation algorithms [PDF]

, 2010
In this paper we present a comparative evaluation of four popular interactive segmentation algorithms. The evaluation was carried out as a series of user-experiments, in which participants were tasked with extracting 100 objects from a common dataset: 25
McGuinness, Kevin, O'Connor, Noel E., O\u27Connor, Noel E.   +2 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Construction of image segmentation system combining TC and swarm intelligence algorithm

Nonlinear Engineering
Considering the slow convergence speed and local optima in most current swarm intelligence algorithms for image segmentation, this study combines the thresholding clustering with intelligent algorithms.
Wang Yongtao
doaj   +1 more source

An efficient approach for optimal multilevel thresholding selection for gray scale images based on improved differential search algorithm

Ain Shams Engineering Journal, 2018
Segmentation is one of the important steps for image analysis. Multilevel thresholding image segmentation was more popular in image segmentation. Otsu and Kapur based methods are most popular for multilevel threshold image segmentation.
Sowjanya Kotte, P. Rajesh Kumar, Satish Kumar Injeti   +2 more
doaj   +1 more source

Object segmentation by fitting statistical shape models : a Kernel-based approach with application to wisdom tooth segmentation from CBCT images [PDF]

, 2014
Image segmentation is an important and challenging task in medical image analysis. Especially from low-quality images, segmentation algorithms have to cope with misleading background clutter, insufficient object boundaries and noise in the image ...
Jud, Christoph
core   +1 more source

Segmentation Of SAR Images

International Geoscience and Remote Sensing Symposium, 'Remote Sensing: Moving Toward the 21st Century'., 1989
Based on an SAR speckle statistical model, the authors investigate the feasibility of segmenting SAR images based on a gray-level histogram for one-look and multilook processed SAR images. The classification errors are evaluated and a procedure for the multilevel thresholding of SAR images is devised.
Lee, J.-S., Jurkevich, I.
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source