Results 81 to 90 of about 248,234 (269)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Optimization and Benchmarking of Image Segmentation for Improved Landmark Detection in Lower Limb X-Rays and Accurate Coronal Plane Alignment of the Knee Classification

IEEE Access
Recent studies have explored image segmentation for landmark detection in computer vision and medical imaging of the lower limb, showing promising results.
Sebastian Amador Sanchez, Ashkan Zarghami, Philippe van Overschelde, Jef Vandemeulebroucke   +3 more
doaj   +1 more source

Semisupervised Soft Mumford-Shah Model for MRI Brain Image Segmentation

Applied Computational Intelligence and Soft Computing, 2016
One challenge of unsupervised MRI brain image segmentation is the central gray matter due to the faint contrast with respect to the surrounding white matter.
Hong-Yuan Wang, Fuhua Chen
doaj   +1 more source

IMAGE SEGMENTATION USING MULTIWAVELET TRANSFORM

Journal of Engineering, 2010
This paper presents region growing image segmentation method which unifies region and boundary information. Several studies shown that segmentation based on image features can improve the accuracy of the interpretation.
Manal Fadel Younis
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Integrating Semi-supervised and Supervised Learning Methods for Label Fusion in Multi-Atlas Based Image Segmentation

Frontiers in Neuroinformatics, 2018
A novel label fusion method for multi-atlas based image segmentation method is developed by integrating semi-supervised and supervised machine learning techniques.
Qiang Zheng, Qiang Zheng, Qiang Zheng, Yihong Wu, Yong Fan   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Fuzzy clustering based transition region extraction for image segmentation

Engineering Science and Technology, an International Journal, 2018
Transition region based approaches are recent hybrid segmentation techniques well known for its simplicity and effectiveness. Here, the segmentation effectiveness depends on the robust extraction of transition regions.
Priyadarsan Parida, Nilamani Bhoi
doaj   +1 more source

Segmenting Dermoscopic Images

CoRR, 2017
We propose an automatic algorithm, named SDI, for the segmentation of skin lesions in dermoscopic images, articulated into three main steps: selection of the image ROI, selection of the segmentation band, and segmentation. We present extensive experimental results achieved by the SDI algorithm on the lesion segmentation dataset made available for the ...
Mario Rosario Guarracino, Lucia Maddalena 0001   +1 more
openaire   +4 more sources