Results 41 to 50 of about 10,081 (286)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A modified K3M thinning algorithm

open access: yesInternational Journal of Applied Mathematics and Computer Science, 2016
The K3M thinning algorithm is a general method for image data reduction by skeletonization. It had proved its feasibility in most cases as a reliable and robust solution in typical applications of thinning, particularly in preprocessing for optical ...
Tabedzki Marek   +2 more
doaj   +1 more source

Testing Foundations of Biological Scaling Theory Using Automated Measurements of Vascular Networks

open access: yes, 2015
Scientists have long sought to understand how vascular networks supply blood and oxygen to cells throughout the body. Recent work focuses on principles that constrain how vessel size changes through branching generations from the aorta to capillaries and
Ennis, Daniel B   +2 more
core   +3 more sources

On skeletonization in 4D images [PDF]

open access: yes, 1996
In this paper we extended the 3D Skeletonization method based on Euler number count & cluster count to 4D. As the Euler sum in 4D is always 0, we solved this by embedding 4D objects in a 5D space to calculate the 5D Euler number. The 5D Euler number changes due to 3 events: 1D tunnels, 2D tunnels and 3D tunnels.
Pieter P. Jonker, Obbe Vermeij
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Segmentation and morphological analysis of amyloid fibrils from cryo-EM image data

open access: yesJournal of Mathematics in Industry, 2023
Fast assessment of the composition of amyloid fibril samples from cryo-EM data poses a serious challenge to existing image analysis tools. We develop a method for automated segmentation of single fibrils requiring only little user input during the ...
Matthias Weber   +6 more
doaj   +1 more source

Image-Based Phenotyping for Non-Destructive In Situ Rice (Oryza sativa L.) Tiller Counting Using Proximal Sensing

open access: yesSensors, 2022
The increase in the number of tillers of rice significantly affects grain yield. However, this is measured only by the manual counting of emerging tillers, where the most common method is to count by hand touching.
Yuki Yamagishi   +3 more
doaj   +1 more source

Brain Tumor Vascular Network Segmentation from Micro-Tomography [PDF]

open access: yes, 2011
Micro-tomography produces high resolution images of bio- logical structures such as vascular networks. In this paper, we present a new approach for segmenting vascular network into pathological and normal regions from considering their micro-vessel 3D ...
Descombes, Xavier   +6 more
core   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

A Comparative Study of Handwritten Character Recognition by using Image Processing and Neural Network Techniques

open access: yesHittite Journal of Science and Engineering, 2021
This study aims to analyze the effects of noise, image filtering, and edge detection techniques in the preprocessing phase of character recognition by using a large set of character images exported from MNIST database trained with various sizes of neural
Hakan Koyuncu
doaj   +1 more source

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