Results 1 to 10 of about 604,468 (284)

Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF

Cell Communication and Signaling, 2023
Background Osteoarthritis is an age-related disease that currently faces a lack of symptomatic treatment. Inflammation, which is mainly sustained by pro-inflammatory cytokines such as IL-1b, TNF, and IL-6, plays an important role in osteoarthritis ...
Anais Defois, Nina Bon, Alexandre Charpentier, Melina Georget, Nicolas Gaigeard, Frederic Blanchard, Antoine Hamel, Denis Waast, Jean Armengaud, Ophelie Renoult, Claire Pecqueur, Yves Maugars, Marie-Astrid Boutet, Jerome Guicheux, Claire Vinatier   +14 more
doaj   +1 more source

Click and bioorthogonal hyaluronic acid hydrogels as an ultra-tunable platform for the investigation of cell-material interactions

Bioactive Materials, 2023
The cellular microenvironment plays a major role in the biological functions of cells. Thus, biomaterials, especially hydrogels, which can be design to mimic the cellular microenvironment, are being increasingly used for cell encapsulation, delivery, and
Nathan Lagneau, Pierre Tournier, Boris Halgand, François Loll, Yves Maugars, Jérôme Guicheux, Catherine Le Visage, Vianney Delplace   +7 more
doaj   +1 more source

Comparison of MRI T1, T2, and T2* mapping with histology for assessment of intervertebral disc degeneration in an ovine model

Scientific Reports, 2022
An easy, reliable, and time-efficient standardized approach for assessing lumbar intervertebral disc (IVD) degeneration with relaxation times measurements in pre-clinical and clinical studies is lacking.
Nora Bouhsina, Cyrille Decante, Jean-Baptiste Hardel, Dominique Rouleau, Jérôme Abadie, Antoine Hamel, Catherine Le Visage, Julie Lesoeur, Jérôme Guicheux, Johann Clouet, Marion Fusellier   +10 more
doaj   +1 more source

A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models

Scientific Reports, 2021
In skeletal surgical procedures, bone regeneration in irregular and hard-to-reach areas may present clinical challenges. In order to overcome the limitations of traditional autologous bone grafts and bone substitutes, an extrudable and easy-to-handle ...
Pierre Tournier, Jérôme Guicheux, Arnaud Paré, Aymeric Maltezeanu, Thibaut Blondy, Joëlle Veziers, Caroline Vignes, Manon André, Julie Lesoeur, Ana Barbeito, Raphaël Bardonnet, Christophe Blanquart, Pierre Corre, Valérie Geoffroy, Pierre Weiss, Alexis Gaudin   +15 more
doaj   +1 more source

Specialized pro-resolving lipid mediators in endodontics: a narrative review

BMC Oral Health, 2021
Endodontics is the branch of dentistry concerned with the morphology, physiology, and pathology of the human dental pulp and periradicular tissues. Human dental pulp is a highly dynamic tissue equipped with a network of resident immunocompetent cells ...
Davy Aubeux, Ove A. Peters, Sepanta Hosseinpour, Solène Tessier, Valérie Geoffroy, Fabienne Pérez, Alexis Gaudin   +6 more
doaj   +1 more source

New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis

Bone Research, 2023
Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases leading to increased bone resorption. Preventing this inflammatory bone resorption is a major health challenge.
Emilie Hascoët, Frédéric Blanchard, Claudine Blin-Wakkach, Jérôme Guicheux, Philippe Lesclous, Alexandra Cloitre   +5 more
doaj   +1 more source

Material‐Assisted Strategies for Osteochondral Defect Repair

Advanced Science, 2022
The osteochondral (OC) unit plays a pivotal role in joint lubrication and in the transmission of constraints to bones during movement. The OC unit does not spontaneously heal; therefore, OC defects are considered to be one of the major risk factors for ...
Constance Lesage, Marianne Lafont, Pierre Guihard, Pierre Weiss, Jérôme Guicheux, Vianney Delplace   +5 more
doaj   +1 more source

An Extrudable Partially Demineralized Allogeneic Bone Paste Exhibits a Similar Bone Healing Capacity as the “Gold Standard” Bone Graft

Frontiers in Bioengineering and Biotechnology, 2021
Autologous bone grafts (BGs) remain the reference grafting technique in various clinical contexts of bone grafting procedures despite their numerous peri- and post-operative limitations.
Pierre Tournier, Pierre Tournier, Jérôme Guicheux, Jérôme Guicheux, Arnaud Paré, Arnaud Paré, Joëlle Veziers, Joëlle Veziers, Ana Barbeito, Raphaël Bardonnet, Pierre Corre, Valérie Geoffroy, Pierre Weiss, Alexis Gaudin   +13 more
doaj   +1 more source

Patch-type Segmentation of Voxel Shapes using Simplified Surface Skeletons [PDF]

, 2008
We present a new method for decomposing a 3D voxel shape into disjoint segments using the shape’s simplified surface-skeleton. The surface skeleton of a shape consists of 2D manifolds inside its volume.
Reniers, Dennie,, Telea, Alexandru,
core   +7 more sources

Clickable Dynamic Bioinks Enable Post‐Printing Modifications of Construct Composition and Mechanical Properties Controlled over Time and Space

Advanced Science, 2023
Bioprinting is a booming technology, with numerous applications in tissue engineering and regenerative medicine. However, most biomaterials designed for bioprinting depend on the use of sacrificial baths and/or non‐physiological stimuli.
Pierre Tournier, Garance Saint‐Pé, Nathan Lagneau, François Loll, Boris Halgand, Arnaud Tessier, Jérôme Guicheux, Catherine Le Visage, Vianney Delplace   +8 more
doaj   +1 more source