Results 31 to 40 of about 217,674 (248)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Terra Brasilis, 2021 Travelers' reports and their impressions of the sea have populated the social imagination since the Middle Ages. These representations of the unknown created many imaginaries.
Lohanne Fernanda Gonçalves Ferreira
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
[Imaginary Landscapes Student Demos 47]
, 2003 Wet on wet landscape in brown and yellow. On same sheet as [Imaginary Landscapes Student Demos 48]Tiff file: 3310x2196 pixels, 20.7 Mb; Display: jpeg, 529x800 pixels ...
Father Edward Catich
core +1 more source
The Polar Mediterranean Imaginary. A Renewed Paradigm by Vilhjalmur Stefansson
Nordicum-MediterraneumSouthern social imaginaries have typically conceived of the North as a frozen and inhospitable area, depriving it of much interest. However, during the first part of the 20th century, the anthropologist and explorer Vilhjalmur Stefansson unveiled many ...
Santiago Villalobos Dantas
doaj +1 more source
A cidade imaginada ou o imaginário da cidade The city imagined, or the city’s imaginary
História, Ciências, Saúde: Manguinhos, 1998 O artigo trata da temática da cidade real-cidade imaginária. Argumenta que, ao refletirmos sobre a cidade, refletimos, também, sobre nós mesmos, com todos os nossos sonhos, frustrações, ansiedades e esperanças.
Maria Aparecida Lopes Nogueira
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
ReS Futurae, 2018 Science-fiction and the imaginary of cosmos bring a fertile framework to video games. Apart the depth of the fictional worlds that it allows to develop, Space void as a narrative and iconographic trope opens a wide variety of issues linked to the ...
Guillaume Baychelier
doaj +1 more source