Results 41 to 50 of about 169,519 (318)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

A cidade imaginada ou o imaginário da cidade The city imagined, or the city’s imaginary

open access: yesHistória, Ciências, Saúde: Manguinhos, 1998
O artigo trata da temática da cidade real-cidade imaginária. Argumenta que, ao refletirmos sobre a cidade, refletimos, também, sobre nós mesmos, com todos os nossos sonhos, frustrações, ansiedades e esperanças.
Maria Aparecida Lopes Nogueira
doaj   +1 more source

THE IMAGINARY OF THE LINGUISTIC IMAGINARY. FOREWORD

open access: yesStudia Universitatis Babeş-Bolyai. Philologia, 2023
The concept of linguistic imaginary is still in the process of being accepted and taken seriously in the Romanian academic world. Although it was coined a few decades ago by Anne-Marie Houdebine-Gravaud (2002), many Romanian linguists regard it with suspicion and are somewhat intrigued by it, considering it a speculative invention (Ardeleanu 2013, 5 ...
Elena PLATON, Ioana-Silvia SONEA
openaire   +1 more source

The Theory of the Imaginary in Geometry, together with the Trigonometry of the Imaginary [PDF]

open access: yesNature, 1920
WHEN we interpret ϕ(x, y)=o, ψ (x, y)-o as the point-equations of two loci, we are bound to consider any values (xi, yi) which satisfy both equations as the co-ordinates of a point common to both curves. The simplest case is when ϕ,ψ are polynomials with ordinary integral coefficients; here the values (xi, y1) are determinate, and can be calculated ...
M., G. B.   +2 more
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Imaginary and Symbolic Forms of Water between Spirit and Culture

open access: yesAcademicus International Scientific Journal
Water is a theme connected to human and social development, not only biologically but also in terms of cultural and identity processes; surprisingly, studies that discuss water from a sociocultural/sociological perspective are scarce.
Eleonora Sparano, Nicola Strizzolo
doaj   +1 more source

Apports de l’iconographie sidérale aux problématiques spatiales vidéoludiques : le cas des jeux vidéo horrifiques

open access: yesReS Futurae, 2018
Science-fiction and the imaginary of cosmos bring a fertile framework to video games. Apart the depth of the fictional worlds that it allows to develop, Space void as a narrative and iconographic trope opens a wide variety of issues linked to the ...
Guillaume Baychelier
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Entre fabrique continue du paysage (post-)industriel et absence de récit commun autour du patrimoine industriel : le cas du bassin stéphanois

open access: yesBulletin de l’Association de Géographes Français
Saint-Étienne, an industrial stronghold until 1918 before becoming an area in crisis, has drawn its roots and its identity from its underground. Today, its landscape reveals not only the traces of this unique industrial epic, but also the signs of its ...
Georges-Henry Laffont, Luc Rojas
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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