Results 61 to 70 of about 79,358 (268)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Entre fabrique continue du paysage (post-)industriel et absence de récit commun autour du patrimoine industriel : le cas du bassin stéphanois

Bulletin de l’Association de Géographes Français
Saint-Étienne, an industrial stronghold until 1918 before becoming an area in crisis, has drawn its roots and its identity from its underground. Today, its landscape reveals not only the traces of this unique industrial epic, but also the signs of its ...
Georges-Henry Laffont, Luc Rojas
doaj   +1 more source

Imaginaries of Prosperity as Constitutional Imaginaries

, 2023
Abstract This chapter explores the question of what renders imaginaries constitutional. Should we expect to find constitutional imaginaries in constitutional texts and doctrine? Or should we look for them elsewhere in our societies? While constitutional documents or conventions have occupied much of our political imagination, the truly ...
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Communication and Identity: An Approximation to the Study of Consumption [PDF]

Universitas Humanística, 2007
To talk about consumer culture is to question the role that capitalist exchange, objects and their dynamics play in today’s world. To understand consumption as an action of meaning and as a problem of anthropological concern brings about valuable data ...
Claudia Constanza Méndez Hernández
doaj  

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Liouville’s imaginary shadow [PDF]

Journal of High Energy Physics, 2012
Abstract $ \mathcal{N}=1 $ super Liouville field theory is one of the simplest non-rational conformal field theories. It possesses various important extensions and interesting applications, e.g. to the AGT relation with 4D gauge theory or the construction of the OSP(1|2) WZW model.
Schomerus, V., Suchanek, P.
openaire   +4 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Exploring the Futures of Datafied Welfare State Education: Thematic Analysis of Sociotechnical Imaginaries

Social Inclusion
Technological developments have inspired many scholars and other professionals to envision the possibilities that digital data technologies bring to the future of education. However, some aspects of this so‐called datafication may conflict with the local
Lauri Palsa, Janne Fagerlund, Pekka Mertala   +2 more
doaj   +1 more source

Imaginary – Tourism

, 2014
It is hard to imagine tourism without the creative use of tempting as well as restrictive imaginaries of both peoples and places. Tourism imaginaries are socially transmitted representational assemblages that interact with people's personal imaginings and are used as meaning-making and world-shaping devices in tourism and beyond.
openaire   +1 more source