Results 51 to 60 of about 217,674 (248)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Exploring the Futures of Datafied Welfare State Education: Thematic Analysis of Sociotechnical Imaginaries

Social Inclusion
Technological developments have inspired many scholars and other professionals to envision the possibilities that digital data technologies bring to the future of education. However, some aspects of this so‐called datafication may conflict with the local
Lauri Palsa, Janne Fagerlund, Pekka Mertala   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

[Imaginary Landscapes Student Demos 27]

, 2003
Wet on wet landscape in blue and brown. On same sheet as [Imaginary Landscapes Student Demos 28]Tiff file: 3340x1920 pixels, 18.3 Mb; Display: jpeg, 460x800 pixels ...
Father Edward Catich
core   +1 more source

L’immaginario politico delle memorie: Brasile 1964-1985 [PDF]

Diacronie. Studi di Storia Contemporanea, 2016
From the numerous forms of symbolic good produced in Brazil and pertaining to the period of the dictatorship, itself a stimulus for political commemoration and constant subject of debate, we have chosen to concentrate on the analysis of books, considered
Lucileide Costa Cardoso
doaj  

Time and chaos: the “imagination of possibilities” and the media

Comunicação e Sociedade, 2019
This article proposes a reflection about the notion of time and its relation to the media based on the complex thinking paradigm and the transdisciplinary perspective.
Gustavo Castro, Florence Dravet
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

[Finished Imaginary Landscapes BOH 1084]

, 2005
Two trees sitting on green background, hilly brown foreground. "8 1/2" written in bottom right corner, "7" written in bottom left.Tiff file: 803 x 1136 pixels, 2.61 Mb; Display: jpeg, 600 x 849 pixels ...
Father Edward Catich
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

[Finished Imaginary Landscapes BOH 1085]

, 2005
Distant blue trees, light brown foreground, dark night sky.Tiff file: 972 x 1142 pixels, 3.18 Mb; Display: jpeg, 600 x 705 pixels ...
Father Edward Catich
core