Results 1 to 10 of about 278,031 (168)

Imaging Biomarkers or Biomarker Imaging? [PDF]

Pharmaceuticals, 2014
Since biomarker imaging is traditionally understood as imaging of molecular probes, we highly recommend to avoid any confusion with the previously defined term “imaging biomarkers” and, therefore, only use “molecular probe imaging (MPI)” in that context.
Markus Mitterhauser, Wolfgang Wadsak
doaj   +3 more sources

Cell segmentation for immunofluorescence multiplexed images using two-stage domain adaptation and weakly labeled data for pre-training

Scientific Reports, 2022
Cellular profiling with multiplexed immunofluorescence (MxIF) images can contribute to a more accurate patient stratification for immunotherapy. Accurate cell segmentation of the MxIF images is an essential step.
Wenchao Han, Alison M. Cheung, Martin J. Yaffe, Anne L. Martel   +3 more
doaj   +1 more source

Quantitative single-cell analysis of immunofluorescence protein multiplex images illustrates biomarker spatial heterogeneity within breast cancer subtypes

Breast Cancer Research, 2021
Background The extent of cellular heterogeneity in breast cancer could have potential impact on diagnosis and long-term outcome. However, pathology evaluation is limited to biomarker immunohistochemical staining and morphology of the bulk cancer.
Alison Min-Yan Cheung, Dan Wang, Kela Liu, Tyna Hope, Mayan Murray, Fiona Ginty, Sharon Nofech-Mozes, Anne Louise Martel, Martin Joel Yaffe   +8 more
doaj   +1 more source

Quantitative Assessment of Intervertebral Disc Composition by MRI: Sensitivity to Diurnal Variation

Tomography, 2023
Whether diurnal variation exists in quantitative MRI indices such as the T1rho relaxation time (T1ρ) of the intervertebral disc (IVD) is yet to be explored.
Hiroyuki Hamaguchi, Maho Kitagawa, Daiki Sakamoto, Ulrich Katscher, Hideki Sudo, Katsuhisa Yamada, Kohsuke Kudo, Khin Khin Tha   +7 more
doaj   +1 more source

Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease

Journal of Neuroinflammation, 2023
Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or a secondary outcome. For that reason, either as diagnostic tools or to monitor progression and/or pharmacological interventions, there is a need
Marta Vicente-Rodríguez, Renzo Mancuso, Alba Peris-Yague, Camilla Simmons, NIMA Consortium, Diego Gómez-Nicola, V. Hugh Perry, Federico Turkheimer, Simon Lovestone, Christine A. Parker, Diana Cash   +10 more
doaj   +1 more source

Microscopic Fractional Anisotropy Detects Cognitive Training-Induced Microstructural Brain Changes

Tomography, 2022
Cognitive training-induced neuroplastic brain changes have been reported. This prospective study evaluated whether microscopic fractional anisotropy (μFA) derived from double diffusion encoding (DDE) MRI could detect brain changes following a 4 week ...
Xinnan Li, Daisuke Sawamura, Hiroyuki Hamaguchi, Yuta Urushibata, Thorsten Feiweier, Keita Ogawa, Khin Khin Tha   +6 more
doaj   +1 more source

A model of k-mer surprisal to quantify local sequence information content surrounding splice regions [PDF]

PeerJ, 2020
Molecular sequences carry information. Analysis of sequence conservation between homologous loci is a proven approach with which to explore the information content of molecular sequences.
Sam Humphrey, Alastair Kerr, Magnus Rattray, Caroline Dive, Crispin J. Miller   +4 more
doaj   +2 more sources

A bioluminescence reporter mouse model for visualizing and quantifying CD8+ T cells in vivo

Neoplasia: An International Journal for Oncology Research, 2022
Cytotoxic CD8+ T cells are the primary effector cells mediating anti-tumor responses. In vivo monitoring of CD8+ T cells has broad implications for the development of novel cancer therapies.
Kimberly Bettano, Mark Zielstorff, Raquel Sevilla, Ruojing Yang, Heather Zhou, Thomas Rosahl, Jie Zhang-Hoover, Lily Y. Moy, Weisheng Zhang   +8 more
doaj   +1 more source

On the Road towards Small-Molecule Programmed Cell Death 1 Ligand 1 Positron Emission Tomography Tracers: A Ligand-Based Drug Design Approach

Pharmaceuticals, 2023
PD-1/PD-L1 immune checkpoint blockade for cancer therapy showed promising results in clinical studies. Further endeavors are required to enhance patient stratification, as, at present, only a small portion of patients with PD-L1-positive tumors (as ...
Karsten Bamminger, Verena Pichler, Chrysoula Vraka, Tina Nehring, Katharina Pallitsch, Barbara Lieder, Marcus Hacker, Wolfgang Wadsak   +7 more
doaj   +1 more source

Quantitative evaluation of hepatic integrin αvβ3 expression by positron emission tomography imaging using 18F-FPP-RGD2 in rats with non-alcoholic steatohepatitis

EJNMMI Research, 2020
Background Integrin αvβ3, which are expressed by activated hepatic stellate cells in non-alcoholic steatohepatitis (NASH), play an important role in the fibrosis.
Shuichi Hiroyama, Takemi Rokugawa, Miwa Ito, Hitoshi Iimori, Ippei Morita, Hiroki Maeda, Kae Fujisawa, Keiko Matsunaga, Eku Shimosegawa, Kohji Abe   +9 more
doaj   +1 more source