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Imaging mass cytometry - elemental immunohistochemistry for multiparametric imaging and quantitation
The Journal of Immunology, 2016Abstract Pathology assessment of tissue sections provides prognostic evaluation and helps select optimum treatment regimens. Digital pathology has made significant strides in the analysis of several markers. There is a growing understanding of cell heterogeneity within tumor tissue, role of microenvironment, and the impact of immune ...
Olga Ornatsky +6 more
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Spatially mapping the immune landscape of melanoma using imaging mass cytometry
Science Immunology, 2022Melanoma is an immunogenic cancer with a high response rate to immune checkpoint inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a result, has abundant tumor-infiltrating lymphocytes (TILs) within its microenvironment. However, understanding the complex interplay between the stroma, tumor cells, and
Dan Moldoveanu +40 more
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Testing a Nanoparticle Reagent for Imaging Mass Cytometry
BiomacromoleculesMass cytometry (MC), a powerful single-cell analysis technique, has limitations in detecting low-abundance biomarkers. Nanoparticle (NP) reagents offer the potential for enhancing sensitivity by carrying large numbers of heavy metal isotopes. Here, we report NP reporters for imaging mass cytometry (IMC) based on NaYF4:Yb3+/Er3+ NPs.
Mahtab Abtahi +9 more
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Imaging Mass Cytometry for In Situ Immune Profiling
The complexities and cellular heterogeneity associated with tissues necessitate the concurrent detection of markers beyond the limitations of conventional imaging approaches in order to spatially resolve the relationships between immune cell populations and their environments.Kevin, Hu +2 more
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Enhancing Mass-Cytometry Imaging Analysis
Inquiry@Queen's Undergraduate Research Conference ProceedingsMass cytometry imaging is a technique that utilizes mass spectrometry instead of fluorescent flow cytometry to detect metal-conjugated antibodies binding to single cell antigens. This method generates multi-dimensional images, a complex data type with significant computational and interpretation challenges due to the absence of a standardized analysis ...
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Spatial immunophenotyping of FFPE tissues by imaging mass cytometry
The immune compartment of a tissue is dynamic, changing to respond to infections, tumors, or therapeutic interventions. Within tissues, local microenvironments provide interaction partners and cytokines that can gear immune cells into distinct functional states. Thus, it is not just the immune composition of a tissue, but also the relative localizationCarolina, Mangana, Barbara B, Maier
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Tailoring inorganic–polymer composites for the mass production of solid-state batteries
Nature Reviews Materials, 2021Li-Zhen Fan, Hongcai He, Ce-Wen Nan
exaly
Artificial channels for confined mass transport at the sub-nanometre scale
Nature Reviews Materials, 2021Jie Shen, Gong-Ping Liu, Yu Han
exaly