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Imaging Mass Cytometry for In Situ Immune Profiling
The complexities and cellular heterogeneity associated with tissues necessitate the concurrent detection of markers beyond the limitations of conventional imaging approaches in order to spatially resolve the relationships between immune cell populations and their environments.Kevin, Hu +2 more
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Spatial immunophenotyping of FFPE tissues by imaging mass cytometry
The immune compartment of a tissue is dynamic, changing to respond to infections, tumors, or therapeutic interventions. Within tissues, local microenvironments provide interaction partners and cytokines that can gear immune cells into distinct functional states. Thus, it is not just the immune composition of a tissue, but also the relative localizationCarolina, Mangana, Barbara B, Maier
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Analysis of the tumor microenvironment using imaging mass cytometry data
The tumor microenvironment (TME) plays a pivotal role in tumor development, influencing interactions with immune cells, tumor progression, and responses to treatment. Understanding the heterogeneity of the TME is essential for uncovering the mechanisms underlying cell-to-cell interactions and their contribution to tumor dynamics. Recent advancements inZuzana, Loncova +2 more
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Imaging Mass Cytometry to Decipher the Maturation of Tertiary Lymphoid Structures
In the realm of inflammation, including conditions like cancers, infections, and autoimmune diseases, the emergence of tertiary lymphoid structures (TLS) holds significant implications for prognosis and treatment response. Yet, traditional methodologies such as immunohistochemistry and immunofluorescence falter in capturing the nuanced complexities of ...Le Rochais, Marion +4 more
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Advances in molecular biology are partially dependent on methodological innovation. Spatially resolved multi-omics, for example, promises to interrogate tissue architectures and mechanisms at unprecedented detail. However, these new experimental techniques introduce computational challenges in disentangling complex data into interpretable bits.
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A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry
Cell Metabolism, 2019Vito Riccardo Tomaso Zanotelli +2 more
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Imaging mass cytometry in preclinical studies of lung cancer
Over the past 50 years, lung cancer has been responsible for the greatest number of cancer-related deaths worldwide. Despite improvements in cancer management and a large research effort toward developing targeted therapies, the 5-year survival rate after a lung cancer diagnosis is still only 23% (Quaresma et al., 2015; Siegel et al., 2023).openaire +2 more sources