Results 111 to 120 of about 117,898 (292)
Nilotinib versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia [PDF]
, 2010 Giuseppe Saglio +15 more
openalex +1 more source
Diagnosing Systemic Mastocytosis: State of the Art
International Journal of Laboratory Hematology, EarlyView.ABSTRACT With the advent of effective multikinase and selective tyrosine kinase inhibitors in systemic mastocytosis, diagnosing this rare disease has been critical to improving patient morbidity and mortality. This state‐of‐the‐art review interprets the international diagnostic criteria, including differences between the WHO 5th edition classification ...
Anton Rets, Tracy I. George
wiley +1 more source
Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools
Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley +2 more sources
Precision medicine in cutaneous melanoma—A comprehensive review
Journal of the European Academy of Dermatology and Venereology, EarlyView.Precision medicine tailors treatment to each patient, beginning with detailed diagnostics. In melanoma, it has advanced considerably: Some methods are in practice and guidelines, while others are commercially available but not routine. This review highlights current and emerging approaches, including molecular profiling, imaging, biomarkers and AI ...
Markus Reitmajer, Lukas Flatz
wiley +1 more source
Structural Basis for the Regulation of PPARγ Activity by Imatinib
Molecules, 2019 Imatinib is an effective anticancer drug for the treatment of leukemia. Interestingly, when an FDA-approved drug library was tested for agents that block peroxisome proliferator-activated receptor γ (PPARγ) phosphorylation at Ser245 to evaluate
Jun Young Jang +2 more
doaj +1 more source
Dermatofibrosarcoma Protuberans in Children: Favorable Outcomes Using Wide Local Excision
Pediatric Dermatology, EarlyView.ABSTRACT Background Dermatofibrosarcoma protuberans (DFSP) is a rare and locally aggressive cutaneous sarcoma. Surgical excision remains first‐line therapy, including for pediatric patients. However, given the rarity of DFSP, specific treatment recommendations for children have not been well defined. To inform pediatric‐specific management, we analyzed
Jawad Aqeel +5 more
wiley +1 more source
Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]
, 2018 Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J +18 more
core +1 more source
DEN Open, Volume 6, Issue 1, April 2026.ABSTRACT Percutaneous biopsy remains the gold standard for diagnosing focal liver lesions; however, endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) has recently emerged as a promising alternative. Although its diagnostic performance is favorable, most available evidence has focused on epithelial tumors, and reports on mesenchymal tumors are ...
Yuichi Takano +9 more
wiley +1 more source
Discontinuation of imatinib in Japanese patients with chronic myeloid leukemia
Haematologica, 2012 It was recently recognized that some chronic myeloid leukemia patients with a complete molecular response could sustain that response after discontinuation of imatinib.
Naoto Takahashi +16 more
doaj +1 more source