Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
MedComm – Oncology, Volume 5, Issue 1, March 2026.Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source
Minimal residual disease in solid tumors: Clinical applications and future directions
Cancer, Volume 132, Issue 3, 1 February 2026.Abstract Minimal residual disease (MRD) refers to the presence of residual cancer cells or tumor‐derived fragments that persist after treatment and remain undetectable by conventional imaging or protein‐based assays. Circulating tumor DNA (ctDNA) has emerged as a dynamic biomarker for MRD detection.
Theresa Abdo +8 more
wiley +1 more source
Ischemic Stroke in Hypereosinophilic Syndrome: A Clinicopathologic Study of Two Cases
Neuropathology, Volume 46, Issue 1, February 2026.ABSTRACT Ischemic stroke is a rare complication of hypereosinophilic syndrome (HES). Manifestations of stroke in HES have been described in the radiologic literature; however the pathologic characterization of central nervous system (CNS) involvement in HES is limited.
Karina C. Martin +3 more
wiley +1 more source
International Journal of Nanomedicine, 2014 Peng Ye,1,2 Wendian Zhang,1 Tan Yang,1 Yao Lu,1 Miao Lu,1 Yongkang Gai,1 Xiang Ma,1 Guangya Xiang1 1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of ...
Ye P +7 more
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A New Era in Anticancer Therapy/Imatinib—A New Era in Anticancer Therapy [PDF]
, 2008 N Danchev +2 more
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JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Hannah Zillikens +15 more
wiley +1 more source
Imatinib in the treatment of chronic myeloid leukemia: current perspectives on optimal dose
Blood and Lymphatic Cancer: Targets and Therapy, 2015 Joanna Waclaw,1 Tomasz Sacha,1 Tomasz Stoklosa,21Department of Hematology, Jagiellonian University Collegium Medicum, Kraków, 2Department of Immunology, Medical University of Warsaw, Warsaw, Poland Abstract: Imatinib was the first tyrosine kinase
Waclaw J, Sacha T, Stoklosa T
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Analysis of imatinib in bone marrow and plasma samples of chronic myeloid leukaemia patients using solid phase extraction LC-ESI-MS [PDF]
, 2011 The LC-ESI-MS was developed and validated for the analysis of imatinib in plasma and bone marrow samples using deuterated imatinib (D(8)-IM) as an internal standard. The biological samples were extracted using Strata-X-C SPE cartridges and separated on C&
Elliott, M. +4 more
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Neoadjuvant Imatinib in Locally Advanced G astrointestinal Stromal Tumors of the Stomach: Report of Three Cases [PDF]
, 2006 Ji Seon Oh +10 more
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Is surgery mandatory in locally advanced gastrointestinal stromal tumors after imatinib? A case report and literature review [PDF]
, 2017 Sabrina Rossi +8 more
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