Results 141 to 150 of about 87,925 (315)

Engineered pulmonary artery tissues for measuring contractility, drug testing and disease modelling

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Vasoreactivity of pulmonary arteries regulates blood flow through the lungs. Excessive constriction of these vessels contributes to pulmonary arterial hypertension (PAH), a progressive and incurable condition, resulting in right heart failure.
Adam L. Fellows, Kate Quigley, Venus Leung, Alexander J. Ainscough, Martin R. Wilkins, Harry Barnett, David Miller, Manuel Mayr, Beata Wojciak‐Stothard   +8 more
wiley   +1 more source

Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations [PDF]

arXiv
The intrinsic dynamics of most proteins are central to their function. Protein tyrosine kinases such as Abl1 undergo significant conformational changes that modulate their activity in response to different stimuli. These conformational changes constitute a conserved mechanism for self-regulation that dramatically impacts kinases' affinities for ...
arxiv  

BCR-ABL point mutants isolated from patients with imatinib mesylate–resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90 [PDF]

, 2002
M. Gorre, Katharine Ellwood‐Yen, Gabriela Chiosis, Neal Rosen, Charles L. Sawyers   +4 more
openalex   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia [PDF]

, 2002
Hagop M. Kantarjian, Susan O’Brien, Jorge E. Cortés, Sergio Giralt, Mary Beth Rios, Jianqin Shan, Francis J. Giles, Deborah A. Thomas, Stefan Faderl, Marcos de Lima, Guillermo Garcia‐Manero, Richard E. Champlin, Ralph B. Arlinghaus, Moshe Talpaz   +13 more
openalex   +1 more source

Interferon-α, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia [PDF]

, 2002
Andreas Burchert, Stefan Wölfl, Manuel Schmidt, Cornelia Brendel, Barbara Denecke, Dali Cai, Larissa Odyvanova, Tanja Lahaye, Martin C. Müller, Thomas Berg, Harald Gschaidmeier, Burghardt Wittig, Rüdiger Hehlmann, Andreas Hochhaus, Andreas Neubauer   +14 more
openalex   +1 more source

Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting

International Journal of Nanomedicine, 2014
Peng Ye,1,2 Wendian Zhang,1 Tan Yang,1 Yao Lu,1 Miao Lu,1 Yongkang Gai,1 Xiang Ma,1 Guangya Xiang1 1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of ...
Ye P, Zhang W, Yang T, Lu Y, Lu M, Gai Y, Ma X, Xiang G   +7 more
doaj  

Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate–resistant Bcr-Abl kinases [PDF]

, 2002
Markus Warmuth, Nicola Simon, Olga Mitina, Ruth Mathes, Doriano Fabbro, Paul W. Manley, Elisabeth Buchdunger, Karin Forster, Ismail Moarefi, Michael Hallek   +9 more
openalex   +1 more source

Incremental Modification in the Existing Approaches for Affinity Chromatographic Enrichment of Phosphoproteins Improves Their Profile in Liquid Chromatography‐Tandem Mass Spectrometry Analysis

Analytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Cell signalling is a vital process in cell physiology, which is driven by protein phosphorylation. Global phosphoproteome analysis by liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) has thus gained importance in cell signalling research.
Neha Agrawal, Rukmini Govekar
wiley   +1 more source

Imatinib in the treatment of chronic myeloid leukemia: current perspectives on optimal dose

Blood and Lymphatic Cancer: Targets and Therapy, 2015
Joanna Waclaw,1 Tomasz Sacha,1 Tomasz Stoklosa,21Department of Hematology, Jagiellonian University Collegium Medicum, Kraków, 2Department of Immunology, Medical University of Warsaw, Warsaw, Poland Abstract: Imatinib was the first tyrosine kinase
Waclaw J, Sacha T, Stoklosa T
doaj