BCR-ABL point mutants isolated from patients with imatinib mesylate–resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90 [PDF]
, 2002 M. Gorre +4 more
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British Journal of Haematology, EarlyView.To identify pathogenic somatic and germline gene variants associated with blast‐phase transformation and cancer predisposition in paediatric chronic myeloid leukaemia (CML), n = 19 patients with blast‐phase paediatric CML were analysed with whole genome and targeted panel sequencing and compared to n = 19 patients with chronic phase paediatric CML.
Yvonne Lisa Behrens +22 more
wiley +1 more source
Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia [PDF]
, 2002 Hagop M. Kantarjian +13 more
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Dasatinib overcomes AML cells resistant to BCL2 inhibition by degrading MCL1
British Journal of Haematology, EarlyView.Summary Acute myeloid leukaemia (AML) is a severe disease occurring mainly in the elderly population. Venetoclax (VEN) combined with azacitidine has changed the paradigm of treatment of AML. Nevertheless, approximately 30% of patients are primary refractory to VEN (VEN‐R), with no current therapeutic option.
Sylvain Garciaz +12 more
wiley +1 more source
Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate–resistant Bcr-Abl kinases [PDF]
, 2002 Markus Warmuth +9 more
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Prevalence of myeloid gene alterations in paediatric cutaneous and systemic mastocytosis
British Journal of Haematology, EarlyView.A total of 69 children with paediatric mastocytosis, including cutaneous and systemic subtypes, were enrolled in a prospective natural history study (NCT00044122). They underwent next‐generation sequencing of peripheral blood to assess myeloid gene alterations.
Xiaoping Sun +4 more
wiley +1 more source
International Journal of Nanomedicine, 2014 Peng Ye,1,2 Wendian Zhang,1 Tan Yang,1 Yao Lu,1 Miao Lu,1 Yongkang Gai,1 Xiang Ma,1 Guangya Xiang1 1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of ...
Ye P +7 more
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Serial monitoring of BCR–ABL by peripheral blood real‐time polymerase chain reaction predicts the marrow cytogenetic response to imatinib mesylate in chronic myeloid leukaemia [PDF]
, 2002 Lihui Wang +4 more
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Organoid Models to Study Human Infectious Diseases
Cell Proliferation, EarlyView.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
The potential role of mitochondrial impairment in the pathogenesis of imatinib-induced renal injury
Heliyon, 2019 Imatinib is a tyrosine kinase inhibitor widely administered against chronic myeloid leukemia. On the other hand, drug-induced kidney proximal tubular injury, electrolytes disturbances, and renal failure is a clinical complication associated with imatinib
Ehsan Emadi +8 more
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