Results 21 to 30 of about 10,308 (152)

Evaluation of imatinib mesylate (Gleevec) on KAI1/CD82 gene expression in breast cancer MCF-7 cells using quantitative real-time PCR

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To evaluate the effect of imatinib mesylate on cell viability, anti cancer effect through modulation of KAI1/CD82 gene expression in breast cancer MCF-7 cell line.
Seyed Ataollah Sadat Shandiz, Marjan Khosravani, Sepideh Mohammadi, Hassan Noorbazargan, Amir Mirzaie, Davoud Nouri Inanlou, Mojgan Dalirsaber Jalali, Hamidreza Jouzaghkar, Fahimeh Baghbani-Arani, Behta Keshavarz-Pakseresht   +9 more
doaj   +1 more source

Prognosic Factors Related to The Complete Hematologic Response (CHR) in 3 Months in Leukemia Granulositic Patients Administered with Imatinib Mesylate

Jurnal Penyakit Dalam Indonesia, 2020
Introduction. The complete hematologic response is an integral part to achieve the complete cytogenetic response target and the major molecular response of imatinib mesylate therapy, although it does not determine the prognosis.
Ikhwan Rinaldi, Ary Harryanto Reksodiputro   +1 more
doaj   +1 more source

Inhibin βB Mediates Oligotrophic Adaptation via Regulating Muscle Satellite Cell Proliferation and Differentiation in Schizopygopsis younghusbandi

Integrative Zoology, EarlyView.
① Nutrient deficiency upregulates inhibin βB, activating SMAD signaling to promote p21. Increased p21 inhibits mcm2/mcm4/mcm5 and cyclin E2, inducing G1‐phase arrest, slowing growth, and reducing energy consumption. ② Inhibin βB also upregulates pdgf‐c, which induces α‐SMA, leading to muscle satellite cell fibrosis.
Weiqiang Li, He Gao, Chaowei Zhou, Luo Lei, Junting Li, Chao Ma, Zitu Ma, Mengwei Yao, Kexin Ma, Yunpeng Xiang, Yan Zhou, Yongrui Lu, Da Ji, Minghong Wei, Luohao Xu, Zhaofang Han, Haiping Liu   +16 more
wiley   +1 more source

SUCCINATE DEHYDROGENASE SUBUNIT B DEFICIENT PEDIATRIC GIST

Hematology, Transfusion and Cell Therapy, 2022
Case report Gastrointestinal stromal tumors (GISTs) occur exceedingly rare in children and adolescents. Eighty five percent of pediatric GISTs and 15 % of adult GISTs lack oncogenic mutations in KIT and PDGFRA.
Melek Yaman Ortakoylu, Sonay Incesoy Ozdemir, Handan Dincaslan, Nurdan Tacyildiz, Isınsu Kuzu, Emel Cabi Unal   +5 more
doaj   +1 more source

Malignant stromal tumor of the stomach with giant cystic liver metastases prior to treatment with imatinib mesylate [PDF]

Vojnosanitetski Pregled, 2013
Introduction. Gastrointestinal stromal tumors (GISTs) are rare and account for 0.1%-3% of all gastrointestinal neoplasms. GISTs are most commonly located in the stomach (60%) and 20%-25% are malignant, with metastases involving the peritoneum or
Čolović Radoje, Micev Marjan, Matić Slavko, Čolović Nataša, Grubor Nikica, Atkinson Dushan Henry   +5 more
doaj   +1 more source

Acute and Chronic Leukemia in Sub‐Saharan Africa: A Systematic Review

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background The four primary subgroups of leukemia include chronic myeloid leukemia (CML), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). Very little is known about the regional variation of leukemia and subtypes in sub‐Saharan Africa (SSA).
Allwell A. Ayirebi, Stephen Twumasi, Linda K. Olaga, Benedict Sackey, Daniel N. M. Antonio, Richard O. Ansah, Eugene A. Ansah, John A. Sah, Enoch O. Anto, Yvonne Anang‐Quartey, Antoinette Koomson, Angela Opoku, Godfred A. Donkor, Paulina Duah, Ama G. Boadu, Samuel Essien‐Baidoo, Wina I. O. Boadu, Lilian A. Boateng   +17 more
wiley   +1 more source

Technoeconomic and sustainability analysis of batch and continuous crystallization for pharmaceutical manufacturing

AIChE Journal, Volume 72, Issue 7, July 2026.
Abstract In pharmaceutical industries, continuous manufacturing methods have already been well established to improve productivity and process intensification. However, to better understand the trade‐offs of continuous crystallizers over the existing batch production systems, a robust technoeconomic cost and sustainability analysis is necessary to ...
Jungsoo Rhim, Zoltan K. Nagy
wiley   +1 more source

Complete response to imatinib treatment in jejunal leiomyosarcoma subsequently developing gastrointestinal stromal tumor and desmoid tumor

American Journal of Experimental and Clinical Research, 2014
A unique case of a 50-year-old Japanese male with jejunal leiomyosarcoma (LMS) who subsequently developed gastrointestinal stromal tumor (GIST) and desmoid tumor (DT) during five years and six months after the initial surgery is reported. The patient was
Yuji Kurihara, Yoshio Sakai, Takeshi Tomita   +2 more
doaj   +2 more sources

Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate

Haematologica, 2011
Background Incubation of chronic myeloid leukemia cells in hypoxia inhibits growth and selects BCR/Abl-independent cells with stem cell properties which are refractory to imatinib-mesylate.
Serena Giuntoli, Michele Tanturli, Federico Di Gesualdo, Valentina Barbetti, Elisabetta Rovida, Persio Dello Sbarba   +5 more
doaj   +1 more source

Congenital Atrophic Dermatofibrosarcoma Protuberans: A Case Report and Narrative Review of the Literature

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Dermatofibrosarcoma protuberans is a rare dermal and subcutaneous soft‐tissue tumor, uncommon in children, characterized by CD34 positivity and COL1A1‐PDGFB fusion. Prognosis is generally good, but local recurrence risk is high, so complete excision with clear margins and six‐monthly follow‐up for three years after surgery is recommended in ...
Sima Shamshiri Khamene, Izat Mohammad Khawajah, Taha Shahbazi, Safoura Shakoei   +3 more
wiley   +1 more source