Results 31 to 40 of about 53,405 (189)
Haematologica, 2011 Background Incubation of chronic myeloid leukemia cells in hypoxia inhibits growth and selects BCR/Abl-independent cells with stem cell properties which are refractory to imatinib-mesylate.
Serena Giuntoli +5 more
doaj +1 more source
The Lancet, 2009 Background Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the intestinal tract. The standard treatment of localized, primary GIST has been surgical resection alone.
R. DeMatteo +14 more
semanticscholar +1 more source
AIChE Journal, Volume 72, Issue 7, July 2026.Abstract In pharmaceutical industries, continuous manufacturing methods have already been well established to improve productivity and process intensification. However, to better understand the trade‐offs of continuous crystallizers over the existing batch production systems, a robust technoeconomic cost and sustainability analysis is necessary to ...
Jungsoo Rhim, Zoltan K. Nagy
wiley +1 more source
Clinical Cancer Research, 2016 Purpose: Gastrointestinal stromal tumors (GIST) generally harbor activating mutations in the receptor tyrosine kinase KIT or in the related platelet-derived growth factor receptor alpha (PDGFRA).
Phillip Zook +8 more
semanticscholar +1 more source
Clinical Case Reports, Volume 14, Issue 7, July 2026.ABSTRACT Dermatofibrosarcoma protuberans is a rare dermal and subcutaneous soft‐tissue tumor, uncommon in children, characterized by CD34 positivity and COL1A1‐PDGFB fusion. Prognosis is generally good, but local recurrence risk is high, so complete excision with clear margins and six‐monthly follow‐up for three years after surgery is recommended in ...
Sima Shamshiri Khamene +3 more
wiley +1 more source
Uveitis – A side effect of imatinib mesylate
Indian Journal of Ophthalmology. Case Reports, 2023 Imatinib mesylate, a BCR-ABL tyrosine kinase inhibitor, is widely used in the management of chronic myeloid leukemia (CML). Although there are a few studies documenting ocular side effects of imatinib, there have been no reports of uveitis caused by ...
BN Kalpana +3 more
doaj +1 more source
Small Structures, Volume 7, Issue 7, July 2026.Surface engineering converts pollen‐derived sporopollenin capsules into functional tools for medicine. Chemical, biological, and physical modifications give these natural carriers new properties. The modified capsules can release drugs on demand, recognize diseased tissues, and assist in diagnosis.
Qian Liu +9 more
wiley +1 more source
Toxics, 2021 Tyrosine kinase inhibitors (TKIs) are designed for targeted cancer therapy. The consumption of these drugs during the last 20 years has been constantly rising.
Tina Elersek +7 more
doaj +1 more source
Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Kinetic profiling of 172 compounds across KIT conformations—including D816V—reveals kinetic fingerprints that predict efficacy, selectivity, resistance, and inhibitors’ ability to stabilize key regulatory elements. Far from a secondary metric, binding kinetics provide mechanistic insights beyond affinity, offering a powerful framework for rational drug
Ana Corrionero +7 more
wiley +1 more source
Indian Journal of Pathology and Microbiology, 2013 Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the intestinal tract. In patients with locally advanced and/or metastatic GIST, the introduction of tyrosine kinase inhibitor, imatinib mesylate, has transformed the ...
Mukul Vij, Susama Patra, Mohamed Rela
doaj +1 more source