Results 31 to 40 of about 10,095 (153)

Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Kinetic profiling of 172 compounds across KIT conformations—including D816V—reveals kinetic fingerprints that predict efficacy, selectivity, resistance, and inhibitors’ ability to stabilize key regulatory elements. Far from a secondary metric, binding kinetics provide mechanistic insights beyond affinity, offering a powerful framework for rational drug
Ana Corrionero, Niall Prendiville, Tatiana Cazorla, Maria Baena‐Nuevo, Röhm Sandra, Emilio Camafeita, Stefan Knapp, Patricia Alfonso   +7 more
wiley   +1 more source

Uveitis – A side effect of imatinib mesylate

Indian Journal of Ophthalmology. Case Reports, 2023
Imatinib mesylate, a BCR-ABL tyrosine kinase inhibitor, is widely used in the management of chronic myeloid leukemia (CML). Although there are a few studies documenting ocular side effects of imatinib, there have been no reports of uveitis caused by ...
BN Kalpana, Akhila Mathew, BC Hemalatha, YD Shilpa   +3 more
doaj   +1 more source

Integrating Single‐Cell and Spatial Transcriptomes in HGSOC to Decipher the Metastasis‐Associated Biomarkers

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT High‐grade serous ovarian cancer (HGSOC) is the most common and lethal histological subtype of ovarian cancer. This study aimed to identify peritoneal metastasis‐associated biomarkers of HGSOC to provide directions for subsequent treatment. Transcriptome data were extracted from the GEO database and literature. Differential expression analysis,
Jing Zhu, Zhicheng Yu, Yang Zhang, Hui Hong, Xiaoli Wang, Shan Jiang, Ying Zhou, Cheng Peng, Hongbo Chen   +8 more
wiley   +1 more source

Formulation and in vitro, in vivo evaluation of effervescent floating sustained-release imatinib mesylate tablet. [PDF]

PLoS ONE, 2015
Imatinib mesylate is an antineoplastic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional imatinib mesylate (Gleevec) tablets produce rapid and relatively high peak blood levels and requires frequent ...
Ali Kadivar, Behnam Kamalidehghan, Hamid Akbari Javar, Ehsan Taghizadeh Davoudi, Nurul Dhania Zaharuddin, Bahareh Sabeti, Lip Yong Chung, Mohamed Ibrahim Noordin   +7 more
doaj   +1 more source

Lethal and Sub-Lethal Effects and Modulation of Gene Expression Induced by T Kinase Inhibitors in Zebrafish (Danio Rerio) Embryos

Toxics, 2021
Tyrosine kinase inhibitors (TKIs) are designed for targeted cancer therapy. The consumption of these drugs during the last 20 years has been constantly rising.
Tina Elersek, Matjaž Novak, Mateja Mlinar, Igor Virant, Nika Bahor, Karin Leben, Bojana Žegura, Metka Filipič   +7 more
doaj   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Roles of TIF1β in Leukemic Stem Cell Through SETDB1‐Dependent and Independent Mechanisms

Cancer Science, Volume 117, Issue 4, Page 896-903, April 2026.
In leukemic stem cell, BCR::ABL cooperates with TIF1β to open chromatin at oncogenes and close chromatin at differentiation regulators, driving leukemic reprogramming. In TIF1β‐deficient stem cell, the loss of TIF1β inverts this balance, showing closed chromatin at oncogenes and open chromatin at differentiation regulators.
Mariko Morii, Sho Kubota, Goro Sashida
wiley   +1 more source

Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Animal Models and Experimental Medicine, Volume 9, Issue 3, Page 462-485, March 2026.
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou, Hui Zhang, Yujia Yu, Feng Cheng, Jie Bao, Chunhan Feng, Xiangqu Yu, Zhao Xia, Rao Ding, Xiang Li   +12 more
wiley   +1 more source

Hepatic metastasis with heterologous rhabdomyoblastic differentiation in a patient with gastrointestinal stromal tumor treated with imatinib

Indian Journal of Pathology and Microbiology, 2013
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the intestinal tract. In patients with locally advanced and/or metastatic GIST, the introduction of tyrosine kinase inhibitor, imatinib mesylate, has transformed the ...
Mukul Vij, Susama Patra, Mohamed Rela
doaj   +1 more source

Atypical Gene Rearrangement of the COL1A1::PDGFB Fusion in Dermatofibrosarcoma Protuberans of the Abdominal Wall: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT The aim of this case report is to introduce the reader to dermatofibrosarcoma protuberans (DFSP). In addition to the general characteristics of this rare skin tumor with possible metastatic potential, we also describe an atypical genetic finding that made our patient's case unique.
Jakub Bejbl, Denisa Drozdková, Martina Peřinová, Jiří Ehrmann   +3 more
wiley   +1 more source