Results 31 to 40 of about 12,515 (211)
Veterinární Medicína, 2019 A seven-year-old Toy Poodle was presented for progressive ataxia and seizure episodes. Magnetic resonance imaging revealed inflammatory lesions in the cerebrum and brainstem.
Joong Hyun Song +6 more
doaj +1 more source
Haematologica, 2011 Background Incubation of chronic myeloid leukemia cells in hypoxia inhibits growth and selects BCR/Abl-independent cells with stem cell properties which are refractory to imatinib-mesylate.
Serena Giuntoli +5 more
doaj +1 more source
Optimized Treatment Schedules for Chronic Myeloid Leukemia [PDF]
, 2016 Over the past decade, several targeted therapies (e.g. imatinib, dasatinib, nilotinib) have been developed to treat Chronic Myeloid Leukemia (CML). Despite an initial response to therapy, drug resistance remains a problem for some CML patients. Recent studies have shown that resistance mutations that preexist treatment can be detected in a substan ...
arxiv +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT The chronic nature of chronic myeloid leukemia (CML) has a negative impact on patients’ health‐related quality of life (HRQOL) and the need for prolonged oral tyrosine kinase inhibitors (TKIs) poses a risk to low or nonadherence over time. This systematic review seeks to analyze HRQOL outcomes and adherence to TKIs among pediatric, adolescent,
Rachel S. Werk +2 more
wiley +1 more source
Cutaneous adverse effects of imatinib mesylate
Northern Clinics of Istanbul, 2015 Abstract Not ...
Doğu, Mehmet Hilmi +3 more
openaire +3 more sources
Andrology, EarlyView.Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert +10 more
wiley +1 more source
Formulation and in vitro, in vivo evaluation of effervescent floating sustained-release imatinib mesylate tablet. [PDF]
PLoS ONE, 2015 Imatinib mesylate is an antineoplastic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional imatinib mesylate (Gleevec) tablets produce rapid and relatively high peak blood levels and requires frequent ...
Ali Kadivar +7 more
doaj +1 more source
Toxics, 2021 Tyrosine kinase inhibitors (TKIs) are designed for targeted cancer therapy. The consumption of these drugs during the last 20 years has been constantly rising.
Tina Elersek +7 more
doaj +1 more source
Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon
Advanced Therapeutics, Volume 8, Issue 4, April 2025.Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap +10 more
wiley +1 more source
Maxillofacial Plastic and Reconstructive Surgery, 2017 Background Imatinib mesylate is an inhibitor of the tyrosine kinase Bcr–Abl and a first-line treatment for Philadelphia chromosome-positive chronic myeloid leukaemia (CML).
Gian Paolo Bombeccari +6 more
doaj +1 more source