Results 41 to 50 of about 22,451 (231)

Crystal structure of X‐prolyl aminopeptidase fromCaenorhabditis elegans: A cytosolic enzyme with a di‐nuclear active site

FEBS Open Bio, 2015
Eukaryotic aminopeptidase P1 (APP1), also known as X‐prolyl aminopeptidase (XPNPEP1) in human tissues, is a cytosolic exopeptidase that preferentially removes amino acids from the N‐terminus of peptides possessing a penultimate N‐terminal proline residue.
Shalini Iyer, Penelope J. La-Borde, Karl A.P. Payne, Mark R. Parsons, Anthony J. Turner, R. Elwyn Isaac, K. Ravi Acharya   +6 more
doaj   +1 more source

Synthesis and Anti-Yeast Evaluation of Novel 2-Alkylthio-4-chloro-5-methyl-N-[imino-(1-oxo-(1H)-phthalazin-2-yl)methyl]benzenesulfonamide Derivatives

Molecules, 2014
Pathogenic fungi are one of the main causes of hospital-related infections. Since conventional antifungals have become less effective because of the increasing fungal resistance to the standard drugs, the need for new agents is becoming urgent. Herein we
Jarosław Sławiński, Aneta Pogorzelska, Beata Żołnowska, Anna Kędzia, Marta Ziółkowska-Klinkosz, Ewa Kwapisz   +5 more
doaj   +1 more source

Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19

Scientific Reports, 2022
SARS-CoV-2 causes major disturbances in serum metabolite levels, associated with severity of the immune response. Despite the numerous advantages of urine for biomarker discovery, the potential association between urine metabolites and disease severity ...
Joseph P. Dewulf, Manon Martin, Sandrine Marie, Fabie Oguz, Leila Belkhir, Julien De Greef, Jean Cyr Yombi, Xavier Wittebole, Pierre-François Laterre, Michel Jadoul, Laurent Gatto, Guido T. Bommer, Johann Morelle   +12 more
doaj   +1 more source

Synthesis, Characterization and Inhibition Effect of a New Schiff Base (E)-3-(((2-amino-4-methylphenyl)imino)methyl) naphthalen-2-ol on the Corrosion of Carbon Steel X48 in acidic medium

International Journal of Electrochemical Science, 2017
In the present investigation a new Schiff base named (E)-3-(((2-amino-4-methylphenyl)imino) methyl)naphthalen-2-ol (L) was synthesized, characterized, and tested as a corrosion inhibitor for Carbon steel X48 in two medium 1 M HCl and 0.5 M H2SO4, the ...
Mouzali Saida, Haffar Djahida, Bouzidi Leila, Bouanane Zohra   +3 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]

, 2010
Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Noeske, Jonas, Schwalbe, Harald (Prof. Dr.), Wöhnert, Jens   +2 more
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A novel rhodamine B fluorescence probe for rapid identification of different amino acids by high efficiency fluorescence spectrum-mass spectrometry

Frontiers in Chemistry
IntroductionRapid detection of amino acids plays an important role in the field of medical diagnosis. By combining Rhodamine B with triphenylamine, a novel double-response fluorescence probe (E)-4-((4-(((3′,6′-bis(diethylamino)-3-oxospiro[isoindoline-1,9′
Xiujie Duan, Tao Jin, Boneng Mao, Shihe Shao, Lei Zhao   +4 more
doaj   +1 more source

High-resolution NMR structure of an RNA model system : the 14-mer cUUCGg tetraloop hairpin RNA [PDF]

, 2010
We present a high-resolution nuclear magnetic resonance (NMR) solution structure of a 14-mer RNA hairpin capped by cUUCGg tetraloop. This short and very stable RNA presents an important model system for the study of RNA structure and dynamics using NMR ...
Nozinovic, Senada, Fürtig, Boris, Jonker, Hendrik R. A., Richter, Christian, Schwalbe, Harald (Prof. Dr.)   +4 more
core   +1 more source

Multiscale Structuring of Hydroxyapatite via Two‐Photon Lithography of Nanocomposites

Advanced Functional Materials, EarlyView.
Hydroxyapatite scaffolds are of great interest in bone tissue engineering applications, ranging from 3D cell culture to regenerative medicine. Using two‐photon lithography of a transparent nanocomposite, hydroxyapatite microstructures with features ranging from submicron to centimeter‐scale are fabricated. This allows to mimic the natural bone geometry,
Leonhard Hambitzer, Jan Mathis Hornbostel, Richard Prediger, Sebastian Kluck, Michael Daub, Cornelia Lee‐Thedieck, Frederik Kotz‐Helmer   +6 more
wiley   +1 more source