Results 41 to 50 of about 52,142 (255)

Effect of Implementing a Dashboard With or Without a Best Practice Alert on HLA‐B*58:01 Testing Rates Among Allopurinol Users at VA Medical Centers

Arthritis Care &Research, EarlyView.
Objective The American College of Rheumatology recommends HLA‐B*58:01 allele testing before the initiation of allopurinol, specifically among Asian and African American/Black patients, due to their increased risk for severe hypersensitivity reactions. However, testing rates remain low at many health care facilities.
Abimbola Fadairo‐Azinge, Gabriela Schmajuk, Sristi Sharma, Colleen P. Flanagan, Sara Faghihi‐Kashani, Ning Zhang, Mary A. Whooley   +6 more
wiley   +1 more source

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

IMMEDIATE AND DELAYED HYPERSENSITIVITY REACTIONS TO PROTON PUMP INHIBITORS: A REVIEW ARTICLE [PDF]

Sanamed
Proton pump inhibitors (PPIs) are among the most widely prescribed medications in clinical practice, primarily used for managing acid-related gastrointestinal disorders. While generally regarded as safe, with adverse effects being rare and typically mild,
Corovic Vahida, Corovic Irfan, Ademovic Vahid, Gegic Altan, Dazdarevic Zecirovic Mirzeta, Corovic Kemal, Suljic Lejla, Corovic Licina Emina, Ziljkic Vahid, Plojovic Haris, Maksic Mladen, Dzankovic Fuad, Vucelj Samir, Suljic Muamer   +13 more
doaj   +1 more source

Penilloic acid is the chief culprit involved in non-IgE mediated, immediate penicillin-induced hypersensitivity reactions in mice

Frontiers in Pharmacology, 2022
Metabolites/impurities (MIs) of penicillin are normally considered to be the main substances inducing immediate hypersensitivity reactions in penicillin treatment.
Dunfang Wang, Jiayin Han, Chen Pan, Chunying Li, Yong Zhao, Suyan Liu, Yushi Zhang, Jingzhuo Tian, Yan Yi, Jingjing Zhu, Chenyue Liu, Yuan Wang, Zhong Xian, Jing Meng, Shasha Qin, Xuan Tang, Fang Wang, Aihua Liang   +17 more
doaj   +1 more source

Transducers Across Scales and Frequencies: A System‐Level Framework for Multiphysics Integration and Co‐Design

Advanced Materials Technologies, EarlyView.
Transducers convert physical signals into electrical and optical representations, yet each mechanism is bounded by intrinsic trade‐offs across bandwidth, sensitivity, speed, and energy. This review maps transduction mechanisms across physical scale and frequency, showing how heterogeneous integration and multiphysics co‐design transform isolated ...
Aolei Xu, Mengyao Xiao, Zhouli Sui, Yinpeng Wang, Daoye Zheng, Yuxin Liu, Luwei Wang, Huajun Liu, Chengkuo Lee   +8 more
wiley   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Consumer preferences for food allergen labeling

Allergy, Asthma & Clinical Immunology, 2017
Background Food allergen labeling is an important tool to reduce risk of exposure and prevent anaphylaxis for individuals with food allergies. Health Canada released a Canadian food allergen labeling regulation (2008) and subsequent update (2012 ...
Carlo A. Marra, Stephanie Harvard, Maja Grubisic, Jessica Galo, Ann Clarke, Susan Elliott, Larry D. Lynd   +6 more
doaj   +1 more source

Anaphylaxis to levetiracetam in an adolescent: a very rare occurence

The Turkish Journal of Pediatrics, 2021
Background. Antiepileptic drugs (AEDs) are among the most common causes of severe delayed-type hypersensitivity reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic ...
Şeyma Kahraman, Şeyda Değermenci, Mehmet Ali Oktay, Deniz Menderes, Okşan Derinöz Güleryüz, Ebru Arhan, Arzu Bakırtaş, Hacer İlbilge Ertoy-Karagöl   +7 more
doaj   +1 more source

Biomarkers of immediate drug hypersensitivity

Allergy, 2023
AbstractImmediate drug hypersensitivity reactions (IDHRs) are a burden for patients and the health systems. This problem increases when taking into account that only a small proportion of patients initially labelled as allergic are finally confirmed after an allergological workup.
Cristobalina Mayorga, Adriana Ariza, Rosa Muñoz‐Cano, Vito Sabato, Inmaculada Doña, Maria J. Torres   +5 more
openaire   +5 more sources

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source