Results 61 to 70 of about 661,741 (245)

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Irreversible Electroporation for Inferior Turbinate Reduction Ablation in Adults

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Inferior turbinate hypertrophy is a common cause of nasal airway obstruction. An optimal surgical approach should provide effective volume reduction while preserving mucosal integrity and minimizing postoperative morbidity. Objective To evaluate the safety and efficacy of irreversible electroporation (IRE) for non‐thermal ablation ...
Narin Nard Carmel Neiderman, Codrut Sarafoleanu, Ionut Tanase, Mihai Alexandru Pascu, Desiderio Passali, Ulugbek Saidakramovich Khasanov, Ulugbek Nuridinovich Vokhidov, Eugenijus Lesinskas, Marius Polianskis, Avraham Abergel   +9 more
wiley   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source

Immediate-type hypersensitivity reactions due to antituberculosis drugs: a successful readministration protocol

, 2015
Dursun, A. Berna/0000-0002-6337-6326Background: Little is known about drug hypersensitivity reactions from antituberculosis drugs. Objective: To determine the frequency, risk factors, and characteristics of immediate-type hypersensitivity reactions from ...
Erkekol, Ferda Öner, Buhari, Gözde Köycü, Güler, Müjgan, Dulkar, Güngör, Özkara, Şeref, Keren, Metin, Kalaç, Nilgün, Dursun, Adile Berna, Dursun, AB, Buhari, GK, Dulkar, G, Keren, M, Güler, M, Özkara, Ş, Erkekol, FERDA, Kalaç, N   +15 more
core   +1 more source

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Repository to: Dual intracellular staining of CD154(CD40L) and cytokines at single cell level: a novel aid to document immediate hypersensitivity to amoxicillin

, 2023
Respository methods, tables and figures to "Dual intracellular staining of CD154(CD40L) and cytokines at single cell level: a novel aid to document immediate hypersensitivity to amoxicillin"
Ebo Didier G., Sabato Vito, Mertens Christel, Van Gasse Athina L., van Houdt Michel, van der Poorten Marie-Line M., Hagendorens Margo M., Elst Jessy   +7 more
core   +1 more source

The Immunology of Immediate and Delayed Hypersensitivity Reaction to Gluten

European Journal of Inflammation, 2008
The immunology of gluten hypersensitivity and celiac disease has been pursued with significant interest in the past 20 years. For the prevention of systemic diseases, most pathogens that gain entry into our bodies must be met with an effective immune ...
A. Vojdani, T. O'Bryan, G.H. Kellermann
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

The transcription factor Nrf2 links Th2-mediated experimental allergy to food preservatives

Frontiers in Immunology
IntroductionImmune-mediated adverse reactions to food allergens are rising at a striking rate, for reasons that are not completely understood. Our previous studies suggest that the stress-activated transcription factor Nrf2 (Nuclear factor erythroid 2 ...
Yining Jin, Allison P. Boss, Allison P. Boss, Jenna K. Bursley, Caitlin Wilson, Venugopal Gangur, Cheryl E. Rockwell   +6 more
doaj   +1 more source