Results 51 to 60 of about 128,779 (258)

RETROSPECTIVE COMPARATIVE STUDY OF BONE LOSS IN IMPLANTS WITH AND WITHOUT IMMEDIATE LOADING IN THE EGAS MONIZ UNIVERSITY CLINIC

Taikomieji tyrimai studijose ir praktikoje, 2019
To evaluate bone loss after three years in implants placed at the implantology consult at the Egas Moniz University Clinic, relating bone loss to the type of loading (conventional or immediate load).
Bárbara Galrinho, Ricardo São João, Francisco Salvado   +2 more
doaj  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Effect of Platelet Rich Fibrin (PRF) on Peri-implant Soft Tissue and Crestal Bone in One-Stage Implant Placement: A Randomized Controlled Trial [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: The viability of Platelet Rich Fibrin (PRF) on enhancement of osseous and associated tissue healing has been substantiated well in literature. However, paucity in the applicability of PRF to enhance peri-implant healing in oral region is
Priyanka Boora, Manu Rathee, Mohaneesh Bhoria   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Stress distribution of an anteriorly placed single implant in different clinical scenarios: a 3D finite element analysis

BMC Oral Health
Background Stress distribution around anterior dental implants may vary depending on implant placement timing and loading protocol. This study aimed to evaluate stress distributions around anteriorly placed single implants under different clinical ...
Elif Öztürk, Nadine Graefin von Krockow, Ricardo Curcio   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

IMMEDIATE LOADING IMPLANTS: REVIEW OF THE CRITICAL ASPECTS

Oral & Implantology, 2017
Modern dentistry have witnessed, a rapid and continuing evolution. Concerning the implant-rehabilitation protocols, they have been redefined in order to satisfy patient's increasing expectations in terms of comfort, aesthetic and shorter treatment period.
Tettamanti, Lucia, Andrisani, C., Bassi, M. Andreasi, Vinci, R., Silvestre-Rangil, J., Tagliabue, A.   +5 more
openaire   +4 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Immediate loading: a new implant technique with immediate loading and aesthetics: Nobel Active™.

ORAL & implantology, 2008
The aim of this study is to evaluate the short time aesthetic and functional outcome of a new implant system, the Nobel Active™. The Nobel Active™ features several innovations such as an extensive self-drilling capacity, axial and radial bone compression and an inward tapered collar allowing for marginal bone maintance an soft tissue stabilization ...
Moretto, D, GARGARI, MARCO, Nordsjo, E, Gloria, F, OTTRIA, LILIANA   +4 more
openaire   +2 more sources