Results 41 to 50 of about 1,001,507 (301)
Oxidation of azaheterocycles by free and immobilized xanthine oxidase and xanthine dehydrogenase [PDF]
, 1979 The objective of the study described in this thesis was to show that enzymes, especially immobilized enzymes, can be advantageously used in synthetic organic chemistry.In Chapter 1 enzymes are introduced and the advantages discussed when these highly ...
Tramper, J.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Immobilization of bromelain on cobalt-iron magnetic nanoparticles (CoFe2O4) for casein hydrolysis
Revista Colombiana de Química, 2020 By means of recycling an enzyme, bromelain was used in casein hydrolysis facilitated by a nanobiocatalyst consisting of bromelain, CoFe2O4 magnetic nanoparticles, chitosan, and glutaraldehyde.
José Mauricio García Colmenares +1 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Immobilization of Vibrio cholerae S1 (NAG) L-Glutaminase on Different Supports
مجلة بغداد للعلوم, 2010 Sixteen Vibrio isolates producing L-glutaminase were obtained from clinical and water samples , one isolate was selected according to its’ highest enzyme productivity , it was identified as Vibrio cholerae (NAG) and coded as V. cholerae S1.
Shatha Salman Hassan
doaj +1 more source
Magnetic graphene oxide, a suitable support in ficin immobilization
Heliyon, 2023 In the present study, we aimed to develop a fast, non-toxic ultrasonic-assisted technique for the preparation of graphene oxide (GO) and GO that were accessorized with Fe3O4 (GO-Fe3O4) for enzyme immobilization.
Z. Tahsiri, M. Niakousari, A. Niakowsari
doaj +1 more source
Imobilização de lipase de Candida antarctica B em quitosana para obtenção de biodiesel por transesterificação do óleo de mamona [PDF]
, 2007 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia QuímicaEste trabalho teve como objetivo principal estudar a imobilização de lipase comercial (Lipozyme CALB L) em esferas de ...
Cruz Júnior, Américo
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source