Results 171 to 180 of about 16,577 (248)

GLP‐1 Receptor Agonist Therapy Is Associated With Lower Risk of Lower Extremity Amputation in Adults With Type 2 Diabetes and Foot Ulcer Without Coded Peripheral Arterial Disease: A Hypothesis‐Generating Real‐World Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To compare lower extremity amputation (LEA) risk in adults with Type 2 diabetes and diabetic foot ulcer (DFU) treated with glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) versus other glucose‐lowering therapy, and to test whether coded peripheral arterial disease (PAD) modifies this association and replicates across comparator ...
Hani Robinson, Mustafa Yassin, Dror Robinson, Mohamad Eisa, Waseem Abu Rashed, Feras Qawasmi, Assil Mahamid, Hamza Murad, Muhammad Khatib   +8 more
wiley   +1 more source

Reduced Risk of MASLD and Cardiometabolic Disease Following Renal Denervation Therapy in Patients With Resistant Hypertension

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Autonomic dysfunction increases the risk of cardio‐kidney‐metabolic (CKM) syndrome including metabolic dysfunction‐associated steatotic liver disease (MASLD), type 2 diabetes (T2D), cardiovascular disease (CVD) and chronic kidney disease (CKD).
Alex E. Henney, Matthew Anson, David R. Riley, Laurent Fauchier, Joel P. Giblett, Gregory Y. H. Lip, Rayaz A. Malik, Daniel J. Cuthbertson, Uazman Alam   +8 more
wiley   +1 more source

Neuropsychiatric Outcomes Associated With GLP‐1 Receptor Agonist Use in Medicare Beneficiaries With Type 2 Diabetes: Variation by Treatment Pattern and Obesity Status

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Glucagon‐like peptide‐1 (GLP‐1) receptors are expressed in brain regions governing mood, reward and stress, yet the neuropsychiatric effects of GLP‐1 receptor agonist (GLP‐1 RA) therapy remain poorly characterized. We estimated associations between GLP‐1 RA use and neuropsychiatric disorders and variation by obesity status and treatment ...
Seo Hyon Baik, Fitsum Baye, Haotian Xian, Kin Wah Fung, Clement J. McDonald   +4 more
wiley   +1 more source

Fate and Immortality in Asia. A Cross-cultural Perspective

This Volume represents one of the outcomes of the activities linked to a research funded by Sapienza University of Rome (RM11916B45F8FE71) entitled Fate and Immortality in Asia: A Cross-cultural Perspective, a multi-disciplinary Project focused on the ...
Donatella Rossi, Rossi, Donatella
core  

Semaglutide, Tirzepatide and Clinically Recorded Alcohol‐Related Outcomes in Type 2 Diabetes: A Target Trial Emulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To compare the risk of incident alcohol use disorder (AUD) among adults with Type 2 diabetes (T2D) initiating semaglutide, tirzepatide or sodium‐glucose cotransporter‐2 inhibitors (SGLT2i). Materials and Methods We conducted a target trial emulation using de‐identified electronic health record data from the TriNetX research network (June ...
Huilin Tang, Bingyu Zhang, Ying Lu, Yiwen Lu, Haoyuan Wang, Christal N. Davis, Henry R. Kranzler, Yong Chen   +7 more
wiley   +1 more source

Sustained Versus Minimal GLP‐1 Receptor Agonist Exposure and Metabolic Outcomes in Older Adults Without Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To compare changes in body mass index (BMI) categories after sustained versus minimal glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) exposure in older adults with obesity and without diabetes. A secondary aim was to compare changes in glycated haemoglobin (HbA1c) categories among those with paired HbA1c measurements.
Reuven Zaritsky, Nili Elior, Talish Razi, Naama Sitry, Alexander Lustman, Sophia Eilat‐Tsanani, Hadar Shahaf, Idan Barzilay, Belle Tamir‐Brahms, Shani Afek, Naama Katz Hanein, Ronen Arbel, Michal Shani   +12 more
wiley   +1 more source

Treatment Patterns, Outcomes and Survival Trends in T‐Cell Prolymphocytic Leukemia: A Nationwide Population‐Based Study in the Netherlands

European Journal of Haematology, EarlyView.
ABSTRACT Background T‐cell prolymphocytic leukemia (T‐PLL) is a rare, aggressive mature T‐cell malignancy with limited therapeutic options. Alemtuzumab remains the backbone of therapy, and fit responders are consolidated with allogeneic stem cell transplantation (alloSCT). However, contemporary population‐level outcomes remain poorly defined.
Mirian Brink, Arie C. van der Spek, Jeanette K. Doorduijn, Koen de Heer, Sabina Kersting, Lidwine W. Tick, Doreen G. te Raa, Hanneke M. van der Straaten, Gerrit Jan Veldhuis, Laurens Laterveer, Rogier Mous, Mark‐David Levin, Kees Meijer, Andre Mulder, M. Nijland, Gerwin Huls, Arnon P. Kater, Mar Bellido   +17 more
wiley   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Selective autophagy pathways in ageing and neurodegeneration: Emerging roles for mitophagy and nucleophagy

The FEBS Journal, EarlyView.
As we age, cells gradually accumulate damage, which can contribute to disease and neurodegeneration. This review explores how two cellular recycling processes, mitophagy and nucleophagy, remove damaged mitochondria and nuclear material, respectively, to maintain cell health and long‐term neuronal homeostasis.
Maria Markaki, Nektarios Tavernarakis
wiley   +1 more source

Doctrine, Narrative and the Formation of Christian Identity: A Conversation with Alister McGrath

International Journal of Systematic Theology, EarlyView.
Abstract This article offers a critical and appreciative response to Alister McGrath’s The Nature of Christian Doctrine, exploring the formation of doctrine as a dynamic communal process rooted in Scripture, liturgy and historical context. It highlights McGrath’s analogy between doctrinal development and scientific method, emphasising the search for a ...
Frances Margaret Young
wiley   +1 more source