Results 161 to 170 of about 16,577 (248)

PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients

open access: yesBrain Pathology, EarlyView.
In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Jakob Nückles   +15 more
wiley   +1 more source

TERT Promoter Mutations Are Preferentially Associated With the ERBB2 G776‐Altered Subtype of HER2‐Mutant NSCLC

open access: yesCancer Science, EarlyView.
A two‐stage clinicogenomic analysis identified and independently validated a preferential association between TERT promoter mutations and the ERBB2 G776‐altered subtype of HER2‐mutant NSCLC, highlighting subtype‐specific genomic heterogeneity. ABSTRACT HER2‐mutant non‐small cell lung cancer (NSCLC) comprises molecularly heterogeneous tumors with ...
Akihiro Yoshimura   +3 more
wiley   +1 more source

Landscape and Time Course of Comprehensive Genomic Profiling Use in Japanese Patients With Cancer: A Retrospective Study

open access: yesCancer Science, EarlyView.
This nationwide C‐CAT study found a substantial gap between new therapeutic options recommended after comprehensive genomic profiling (CGP) and their implementation. CGP also identified additional druggable alterations, while receipt of expert panel–recommended therapy was associated with longer overall survival, highlighting the importance of timely ...
Kuniko Sunami   +4 more
wiley   +1 more source

Delusions of Immortality in a Post-War Society: The Albanian Case

open access: yesFrontiers in Psychiatry, 2019
Gentian Vyshka, Ariel Çomo
doaj   +1 more source

‘I like to dance with the flowers!’: Exploring the possibilities for biodiverse futures in an urban forest school

open access: yesChildren &Society, EarlyView.
Abstract This article explores the ways in which ‘forest school’, an educational approach where children engage in creative and play based activities in a ‘natural’ environment, can contribute towards Sustainable Development Goal 15 (SDG 15) by promoting sustainable use of terrestrial ecosystems and by helping address biodiversity loss. Drawing on data
Hannah Hogarth
wiley   +1 more source

Magical Realist Hauntings in Children's Everyday Encounters With Death, or, How to Believe in Impossible Things

open access: yesChildren &Society, EarlyView.
ABSTRACT Modern deaths have become reiterations. That is, despite exhibiting a seemingly high‐level of diversity in death's representations in everyday lives, death suffers from a particular onto‐epistemological poverty that prevents it from being imagined otherwise.
Zhaoxi Zheng   +2 more
wiley   +1 more source

‘Do You Realise People Are Dying There?!’: Ukrainian Adolescents Reflecting on Death During Wartime

open access: yesChildren &Society, EarlyView.
ABSTRACT This article explores how Ukrainian refugee adolescents in Romania think and speak about death and loss amid war and displacement. While contemporary Western societies display an unprecedented visibility of death, they continue to exclude children from genuine conversations about mortality, maintaining a protective silence.
Adriana Teodorescu, Alina Bărbuță
wiley   +1 more source

Improvement of overall survival in patients with cutaneous melanoma at a tertiary care center in Germany from 2001 to 2020

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Systemic treatment of cutaneous melanoma has changed since 2011, with clinical studies demonstrating improved outcomes. This analysis evaluated whether this improvement is evident in a real‐world cohort, focusing on overall survival (OS) and relapse‐free survival (RFS).
Lena Nanz   +7 more
wiley   +1 more source

Early sodium‐glucose co‐transporter 2 inhibitor initiation is associated with improved cardiovascular outcomes in type 2 diabetes and acute coronary syndrome

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Sodium‐glucose co‐transporter 2 inhibitors have demonstrated cardiovascular benefits in individuals with type 2 diabetes mellitus, but the optimal timing of initiation in those with acute coronary syndrome is not known. This study aims to assess if early therapy at discharge is superior to delayed or no therapy in reduction in major ...
Muhammad Usman Shah   +7 more
wiley   +1 more source

Outcomes for post‐transplant relapsed acute lymphoblastic leukaemia in the era of novel therapies: A retrospective multicentre UK study

open access: yes
British Journal of Haematology, EarlyView.
Alexandros Rampotas   +16 more
wiley   +1 more source

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