Results 41 to 50 of about 117,212 (327)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Живое универсальное разумное существо, остоящее из сознания и тела-трансформера [PDF]
Философия и космология, 2012 The problem of the survival and development of Homo sapiens put the need for a radical extension of human life on the agenda in the XXI century. Among the many possible scenarios, there is extreme radical scenario of human transformation and the creation
Кричевский С. В.
doaj
Lucretius on Imagination and Mental Projection
Aitia, 2020 Lucretius sometimes speaks of the mind ‘projecting’ itself, echoing the Epicurean Greek technical term epibolē. The way in which he and other first-century BCE Epicureans use this concept, however, elevates it beyond anything we can find in Epicurus, and
David Sedley
doaj +1 more source
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
, 2019 Purpose of the article is to identify the religious factor in the teaching of transhumanism, to determine its role in the ideology of this flow of thought and to identify the possible limits of technology interference in human nature.
Halapsis, Alex V.
core +3 more sources
Hydroxychloroquine Associated With Lower Glomerular Filtration Rate Decline in Lupus Nephritis
Arthritis Care &Research, EarlyView.Objective Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long‐term benefits of HCQ on kidney function preservation is critical.
Shivani Garg +9 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective We aimed to identify unique disease trajectories within rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) based on longitudinal forced vital capacity (FVC) values and their associated clinical outcomes. Methods We performed a cohort study of RA‐ILD within the Veterans Health Administration from 1999 to 2021.
Bryant R. England +9 more
wiley +1 more source
A note on Huemer’s Claim to immortality
Principia: An International Journal of Epistemology, 2020 According to Huemer (2019), existence is evidence of immortality, provided past time is infinite. The argument is based on, inter alia, an alleged contradiction between the fact of one’s existence now and its improbability.
Inge-Bert Täljedal
doaj +1 more source
Death and Immortality in Middle-earth (2017) edited by Daniel Helen [PDF]
, 2018 Book review by Amy Amendt-Raduege of Death and Immortality in Middle-earth (2017), edited by Daniel ...
Amendt-Raduege, Amy
core +1 more source